Wilderness Medical Society snowmass 2005 Page 56
7
METHOD
· Double-blind, placebo controlled,
matched cohort groups
· Standardized ascent (1700m-4300m in 1
hour)
· Controlled activity, nutrition, hydration
· Ginkgo Dose: 120mg 2 X per day; 5 days
before ascent and during exposure
RESULTS
0
0.4
0.8
1.2
1.6
2
Placebo vs. Ginkgo: ESQ III Scores and
AMS Incidence
Placebo
Ginkgo
A
M
S
I
n
c
i
d
e
n
c
e
(
%
)
0
100
70
30
Severity
Incidence
E
S
Q
S
c
o
r
e
* p<0.05
*
*
· #26 s.l. to 4200m over 2 hrs, RCT
· GB 60 mg tid x 24hrs
· LLS > 3, with headache
· AMS: 7/12 on GB, 13/14 Placebo, p=0.07
· Severe AMS: 2/12 on GB, 9/14 Pl, p=0.02
· Conclusion: GB reduces severity of AMS
when given x 24hrs prior to rapid ascent
· 487/614 trekkers from 4300 to 4928m
· GB, PL, AZ, AZ+GB; 3 or 4 doses
· GB 120 mg bid, AZ 250 mg bid
