7
BioTech Navigator, August 1997
Earnings Per Share
C Yr Next Yr(E)
Product
Indication
Clinical Stage
-2.75 .44
MMPS
Rheumatoid Arthritis
Research
-1.07 -.55
Apogens
Lupus nephritis/rheumatoid arthritis
Preclinical
2.83 3.17
TNF-bp, IL-1ra
Rheumatoid Arthritis
Preclinical, Phase lla
-.40 -.37
AnergiX/AnervaX
Multiple Sclerosis/Rheumatoid Arthritis
Phase l,Phase 11a
-.55 -.83
T-cell activation
Rheumatoid Arthritis & others
Research & development
-.54 -.68
APC-366
Anti-inflammatory/asthma
Phase 11a
-1.29 NA
CT-3
Anti-inflammatory
Research & development
-1.62 -1.78
Myloral, colloral
Multiple Sclerosis, Rheumatoid Arthritis
Phase lll, Phase ll
-1.04 -.84
BCX-34
Rheumatoid Arthritis
Preclinical
-.60 NA
C-MAF
Autoimmune/Allergies
Preclinical
.51 1.16
CenTNF
Rheumatoid Arthritis, Crohn's disease
Phase lll (11 Japan)
-1.49 -.50
CMT (tetracyclines)
Rheumatoid Arthritis
Preclinical
-2.74 -2.34
Ridaura/TCR vaccine
Rheumatoid Arthritis/MS & RA
1
Phase lll/Phase ll
.35 NA
HNE
Rheumatoid Arthritis, OPD & IBD
2
Research & Development
-.65 -.61
Integrin (CY-9652)
MS & RA
1
, Asthma,
Research & Development
-.45 -.28
Primatized IDEC-CE9
MS, RA, SLE, & IBD
3
, Psoriasis
Phase lll
-1.57 -1.62
Immune-based therapy
Rheumatoid Arthritis, Psoriasis/MS
4
Phase ll/Phase l
-.74 -.56
Enbrel-TNFR
Rheumatoid Arthritis
Phase lll
-1.04 -1.19
ISIS 2302
See footnote 5
Phase ll
.97 NA
CD4, CD2
Autoimmune disease/transplant rejection
Preclinical
.03 NA
Immuomodulation
MS & RA
1
, transplantation, diabetes
Screening
-1.43 -.48
Generic Neoral
6
Advanced Rheumatoid Arthritis
NDA filed
.50 NA
TP10
MS & RA
1
, Organ transplant, lupus
Research & development
-1.23 -.04
VX-497
RA
3
, SLE
7
, Asthma, Psoriasis
Preclinical
1. Multiple Sclerosis & rheumatoid Arthritis 6. Neoral is Novartis' tradename
2. Rheumatoid Arthritis, obstructive pulmonary disease, inflammatory bowel disease 7. Systemic Lupus Erythematosus
3. Multiple Sclerosis, rheumatoid Arthritis, systemic lupus erythermatosos, inflammatory bowel disease
4. Multiple Sclerosis
5. Renal transplant rejection, rheumatoid arthritis, ulcerative colitis, crohn's disease
