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Sample Record
Title:
Two controlled trials of antibiotic treatment in patients with
persistent symptoms and a history of Lyme disease.
Author(s):
Klempner, Mark S.; Hu, Linden T.; Evans, Janine; Schmid,
Christopher H.; Johnson, Gary M.; Trevino, Richard P.; Norton, DeLona;
Levy, Lois; Wall, Diane; McCall, John; Kosinski, Mark; Weinstein, Arthur
Author Affiliation:
Department of Medicine, Boston University School of
Medicine, 715 Albany St., Boston, MA, 02118, USA
Author Email(s):
klempner@bu.edu
Source:
New England Journal of Medicine, July 12, 2001, Vol. 345, iss. 2,
pp. 85-92.
Publication Year:
2001
Abstract:
Background: It is controversial whether prolonged antibiotic
treatment is effective for patients in whom symptoms persist after the
recommended antibiotic treatment for acute Lyme disease. Methods: We
conducted two randomized trials: one in 78 patients who were seropositive
for IgG antibodies to Borrelia burgdorferi at the time of enrollment and the
other in 51 patients who were seronegative. The patients received either
intravenous ceftriaxone, 2 g daily for 30 days, or matching intravenous
and oral placebos. Each patient had well-documented, previously treated
Lyme disease but had persistent musculoskeletal pain, neurocognitive
symptoms, or dysesthesia, often associated with fatigue. The primary
outcome measures were improvement on the physical- and mental-health-
component summary scales of the Medical Outcomes Study 36-Item
Short-Form General Health Survey (SF-36) a scale measuring the
health-related quality of life on day 180 of the study. ...
Major Concepts:
Infection; Clinical Immunology (Human Medicine,
Medical Sciences) Pharmacology
Super Taxa:
Hominidae: Primates, Mammalia, vertebrata, Chordata,
Animalia; Spirochaetaceae: Spirochaetales, Spirochetes, Eubacteria,
Bacteria, Microorganisms
Taxa Notes:
Animals; Bacteria; Chordates; Humans; Mammals;
Microorganisms; Primates; Vertebrates
Organisms:
Borrelia burgdorferi (Spirochaetaceae): pathogen; human
(Hominidae): female, host, male, patient
Miscellaneous Terms:
dysesthesia; fatigue; health-related qualify of life;
musculoskeletal pain; neurocognitive symptoms; persistent symptoms
Methods & Equipment:
antibiotic treatment: therapeutic method; planned
interim analysis: analytical method
Concept Codes:
10060* 10064-12512-22002-22005-31000-34502-34508-
36002-38504-
Biosystematic Codes:
06112 86215
Language:
English
Summary Language:
English
ISSN:
00284793
Document Information:
Publication Type: Article. Record Type: Abstract.
Media Type:
print. Update Code: 20010717
Accession Number:
BACD200100232160
Copyright:
Biological Abstracts is copyrighted by Biological Abstracts, Inc.
(BIOSIS). All rights reserved. No part of this information may be
reproduced in hard copy, machine readable or other format without the
express written consent of BIOSIS, except for the print or download
capabilities of the retrieval software used to access it.
Database:
Biological Abstracts 2001
This program and the databases contained herein are protected by U.S. and International
copyright laws.
EBSCOhost ® is a service of EBSCO Publishing, a part of the EBSCO Information
Services group. © 2001
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