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200000170837

Successful ribavirin therapy for severe adenovirus hemorrhagic cystitis after
allogeneic marrow transplant from close HLA donors rather than distant donors.
Author (AU):

Miyamura K(a); Hamaguchi M; Taji H; Kanie T; Kohno A; Tanimoto

M; Saito H; Kojima S; Matsuyama T; Kitaori K; Nagafuji K; Sato T; Kodera Y
Author Address (CS):

(a)First department of internal medicine, Nagoya University

School of Medicine, Tsurumai-cho 65, Showa-ku, Nagoya, 466-8550, Japan
Journal (JN):

Bone Marrow Transplantation. 25 ( 5 ): p 545-548 March, 2000

ISSN (SN):

0268-3369

Document Type (DT):

Article

Record Type (RT):

Abstract

Language (LA):

English

Summary Language (LS):

English

Abstract (AB):

Intravenous ribavirin was given to nine patients who had

developed severe adenovirus-induced hemorrhagic cystitis (AD-HC) which was
resistant to conventional therapy or where there was involvement of other organs
after allogeneic BMT. Three patients recovered completely from AD-HC, two of
whom had been ... Thus, ribavirin seems to be very effective for severe AD-HC
for some recipients who receive transplants from a genetically close donor.
Registry Numbers (RN):

36791-04-5: RIBAVIRIN

Descriptors (DE):

Major Concepts (MC):

Infection; Hematology (Human Medicine, Medical

Sciences); Pharmacology
Biosystematic Names (BN):

Adenoviridae--Animal Viruses, Viruses,

Microorganisms; Hominidae--Primates, Mammalia, Vertebrata, Chordata, Animalia
Organisms (OI):

adenovirus (Adenoviridae)--pathogen; human (Hominidae)--

patient, adult
Biosystematic Classification (Super Taxa) (BC):

Animal Viruses; Animals;

Chordates; Humans; Mammals; Microorganisms; Primates; Vertebrates; Viruses
Diseases (DS):

adenovirus-induced hemorrhagic cystitis {AD-HC}--urologic

disease, viral disease
Chemicals & Biochemicals (NA) or (SY):

HLA; ribavirin--antiviral-drug

Methods & Equipment (MQ):

allogeneic marrow transplantation--therapeutic method

Miscellaneous Terms (MI):

clinical symptoms

Concept Codes (CC):
15008 Blood, Blood-Forming Organs and Body Fluids-Lymphatic Tissue and

Reticuloendothelial System

11107 Anatomy and Histology, General and Comparative-Regeneration and

Transplantation (1971- )

12512 Pathology, General and Miscellaneous-Therapy (1971- )
22005 Pharmacology-Clinical Pharmacology (1972- )
36006 Medical and Clinical Microbiology-Virology
38506 Chemotherapy-Antiviral Agents
34508 Immunology and Immunochemistry-Immunopathology, Tissue Immunology
15506 Urinary System and External Secretions-Pathology
10062 Biochemical Studies-Nucleic Acids, Purines and Pyrimidines
Biosystematic Codes (BC):
02601 Adenoviridae (1993- )
86215 Hominidae

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