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Sample Record
Accession number & update (AN)
: PREV200000170837 20000505.
Author(s) (AU):
Miyamura-K {a}, Hamaguchi-M, Taji-H, Kanie-T, Kohno-A,
Tanimoto-M, Saito-H, Kojima-S, Matsuyama-T, Kitaori-K, Nagafuji-K, Sato-T,
Kodera-Y.
Title (TI):
Successful ribavirin therapy for severe adenovirus hemorrhagic cystitis
after allogeneic marrow transplant from close HLA donors rather than distant
donors.
Source (SO):
Bone-Marrow-Transplantation., March, 2000, vol. 25, no. 5, p. 545-548
ISSN: 0268-3369.
Author affiliation (IN):
University School of Medicine, Tsurumai-cho 65, Showa-ku, Nagoya, 466-
8550, Japan.
Language (LA):
English (EN)
Language of summary: English (EN).
Publication year (YR)
: 2000.
Publication type (PT):
Article.
Descriptors (DE)
Major Concepts (MC):
Infection; Hematology (Human-Medicine Medical-
Sciences); Pharmacology.
Organisms (OR):
adenovirus (Adenoviridae): pathogen; human (Hominidae):
patient, adult
Adenoviridae: Animal-Viruses, Viruses, Microorganisms; Hominidae:
Primates, Mammalia, Vertebrata, Chordata, Animalia.
Diseases (DS):
adenovirus-induced-hemorrhagic-cystitis [AD-HC]:
urologic-disease, viral-disease.
Chemicals & Biochemicals (CB):
HLA; ribavirin: antiviral-drug.
Methods & Equipment (MQ):
allogeneic-marrow-transplantation:
therapeutic-method.
Miscellaneous Descriptors (MI):
clinical symptoms
Concept codes (CC)
15008* Blood, Blood-Forming Organs and Body Fluids-Lymphatic Tissue and
Reticuloendothelial System;
11107* Anatomy and Histology, General and Comparative-Regeneration and
Transplantation (1971- );
12512* Pathology, General and Miscellaneous-Therapy (1971- );
22005* Pharmacology-Clinical Pharmacology (1972- );
36006* Medical and Clinical Microbiology-Virology;
38506* Chemotherapy-Antiviral Agents;
34508* Immunology and Immunochemistry-Immunopathology, Tissue
Immunology;
15506* Urinary System and External Secretions-Pathology;
10062* Biochemical Studies-Nucleic Acids, Purines and Pyrimidines.
Biosystematic codes (BC)
02601 Adenoviridae (1993- );
86215 Hominidae.
Super taxonomic groups
: Animal-Viruses# Animals# Chordates# Humans#
Mammals#, Microorganisms#, Primates#, Vertebrates#, Viruses#.
CAS Registry number (RN):
CAS: 36791-04-5: RIBAVIRIN.
Abstract (AB):
Intravenous ribavirin was given to nine patients who had developed
severe adenovirus-induced hemorrhagic cystitis (AD-HC) which was resistant to
conventional therapy or where there was involvement of other organs after allogeneic
BMT. Three patients recovered completely from AD-HC, two of whom had been resist-
ant to vidarabine. All three had received sibling BMTs (2 HLA matched, 1 HLA mismatched).
Five patients who received BMTs from related (2 HLA mismatched) or unrelated (1 HLA
matched, 2 HLA mismatched) showed an improvement in symptoms but had recurrent
.
.
.
One patient experienced severe pancytopenia during the second treatment with ribavirin
after HC recurrence and recovered after ceasing ribavirin. Thus, ribavirin seems to be
very effective for severe AD-HC for some recipients who receive transplants from a
genetically close donor.
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Accession number & update
00126 MAJOR CONCEPTS 19981204.
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