AN
2000:170837 BIOSIS
Document Number (DN) PREV200000170837
Title (TI)
Successful ribavirin therapy for severe adenovirus hemorrhagic cystitis after allogeneic marrow transplant from close HLA donors rather than distant
donors.
Author(s) (AU)
Miyamura, K. (1); Hamaguchi, M.; Taji, H.; Kanie, T.; Kohno, A.; Tanimoto, M.; Saito, H.; Kojima, S.; Matsuyama, T.; Kitaori, K.; Nagafuji, K.; Sato, T.;
Kodera, Y.
Author Address (CS)
Source (SO)
Bone Marrow Transplantation., (March, 2000) Vol. 25, No. 5, pp. 545-548.
ISSN: 0268-3369.
Document type (DT)
Article
Language (LA)
English
Summary Language (SL) English
Abstract (AB)
Intravenous ribavirin was given to nine patients who had developed severe adenovirus-induced hemorrhagic cystitis (AD-HC) which was resistant to
conventional therapy or where there was involvement of other organs after allogeneic BMT. Three patients recovered completely from AD-HC, two of
whom had been resistant to vidarabine. All three had received sibling BMTs (2 HLA matched, 1 HLA mismatched). Five patients who received BMTs
from related (2 HLA mismatched) or unrelated (1 HLA matched, 2 HLA mismatched) showed an improvement in symptoms but had recurrent AD-HC
after discontinuation of ribavirin........
Concept Codes (CC)
Blood, Blood-Forming Organs and Body Fluids - Lymphatic Tissue and Reticuloendothelial System *15008
Anatomy and Histology, General and Comparative - Regeneration and Transplantation *11107
Pathology, General and Miscellaneous - Therapy *12512
Pharmacology - Clinical Pharmacology *22005
Medical and Clinical Microbiology - Virology *36006
Chemotherapy - Antiviral Agents *38506
Immunology and Immunochemistry - Immunopathology, Tissue Immunology *34508
Urinary System and External Secretions - Pathology *15506
Biochemical Studies - Nucleic Acids, Purines and Pyrimidines *10062
Biosystematic Codes (BC) Adenoviridae 02601
Index Term (IT)
IT Major Concepts (MC)
Infection; Hematology (Human Medicine, Medical Sciences); Pharmacology
IT Diseases (DS)
adenovirus-induced hemorrhagic cystitis [AD-HC]: urologic disease, viral disease
IT Chemicals & Biochemicals (CB)
HLA; ribavirin: antiviral - drug
IT Methods & Equipment (MQ)
allogeneic marrow transplantation: therapeutic method
IT Miscellaneous Descriptors (MI)
clinical symptoms
ORGN Super Taxa
Adenoviridae: Animal Viruses, Viruses, Microorganisms; Hominidae: Primates, Mammalia, Vertebrata, Chordata, Animalia
ORGN Organism Name
adenovirus (Adenoviridae): pathogen; human (Hominidae): patient, human
ORGN Organism Superterms
Animal Viruses; Animals; Chordates; Humans; Mammals; Microorganisms; Primates; Vertebrates; Viruses
CAS Registry Number (RN) 36791-04-5 (RIBAVIRIN)
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