12417335 BIOSIS NO.(AA): 200000170837
Successful ribavirin therapy for severe adenovirus hemorrhagic cystitis after allogeneic marrow transplant from close HLA donors rather than distant donors.
AUTHOR (AU): Miyamura K(a); Hamaguchi M; Taji H; Kanie T; Kohno A; Tanimoto M; Saito H; Kojima S; Matsuyama T; Kitaori K; Nagafuji K; Sato T; Kodera Y
AUTHOR ADDRESS (CS): (a)First department of internal medicine, Nagoya University School of Medicine, Tsurumai-cho 65, Showa-ku, Nagoya, 466-8550**Japan 2000
JOURNAL (JN): Bone Marrow Transplantation. 25 (5):p545-548 March, 2000
ISSN (SN): 0268-3369
DOCUMENT TYPE (DT): Article
RECORD TYPE (RT): Abstract
LANGUAGE (LA): English
SUMMARY LANGUAGE (LS): English
ABSTRACT (AB): Intravenous ribavirin was given to nine patients who had developed severe adenovirus-induced hemorrhagic cystitis (AD-HC) which was resistant to
conventional therapy or where there was involvement of other organs after allogeneic BMT. Three patients recovered completely from AD-HC, two of whom had been
resistant to vidarabine. All three had received sibling BMTs (2 HLA matched, 1HLA mismatched). Five patients who received BMTs from related (2 HLA mismatched)
or unrelated (1HLA matched, 2 HLA mismatched) showed an improvement in symptoms but had recurrent AD-HC...
REGISTRY NUMBERS (RN): 36791-04-5: RIBAVIRIN
DESCRIPTORS (DE):
MAJOR CONCEPTS (MC): Infection; Hematology (Human Medicine, Medical Sciences); Pharmacology
BIOSYSTEMATIC NAMES (BN): Adenoviridae--Animal Viruses, Viruses, Microorganisms; Hominidae--Primates, Mammalia, Vertebrata, Chordata, Animalia
ORGANISMS (OI): adenovirus (Adenoviridae)--pathogen; human (Hominidae)--adult, patient
BIOSYSTEMATIC CLASSIFICATION (SUPER TAXA)(BC): Animal Viruses; Animals; Chordates; Humans; Mammals; Microorganisms; Primates; Vertebrates; Viruses
DISEASES (DS): adenovirus-induced hemorrhagic cystitis [AD-HC]--urologic disease, viral disease
CHEMICALS & BIOCHEMICALS (NA) or (SY): HLA; ribavirin--antiviral-drug
METHODS & EQUIPMENT (MQ): allogeneic marrow transplantation--therapeutic method
MISCELLANEOUS DESCRIPTORS (MI): clinical symptoms
CONCEPT CODES (CC):
15008 Blood, Blood-Forming Organs and Body Fluids-Lymphatic Tissue and Reticuloendothelial System
11107 Anatomy and Histology, General and Comparative-Regeneration and Transplantation (1971- )
12512 Pathology, General and Miscellaneous-Therapy (1971- )
22005 Pharmacology-Clinical Pharmacology (1972- )
36006 Medical and Clinical Microbiology-Virology
38506 Chemotherapy-Antiviral Agents
34508 Immunology and Immunochemistry-Immunopathology, Tissue Immunology
15506 Urinary System and External Secretions-Pathology 10062 Biochemical Studies-Nucleic Acids, Purines and Pyrimidines
BIOSYSTEMATIC CODES BC):
02601 Adenoviridae (1993- )
86215 Hominidae
Searching
BIOSIS Previews
Sample Dialog Article Record
s
www.biosis.org s Training & Support s PowerPoint Presentation s BIOSIS Previews s
s
www.biosis.org/training_support/ s
15
