Subject Information: Title, Abstract, Added Keywords,
Concept Codes, Biosystematic Codes, and Super
Taxonomic Groups
Title: A spontaneous point mutation in the human T-cell leukemia virus type 1 Px gene leads to
expression of a novel doubly spliced Px-MRNA that encodes a 25-Kd, amino-terminal deleted
rex protein
Abstract: Primary RNA transcripts of the human T-cell leukemia virus type 1 (HTLV-1) are processed into
mature MRNA by a complex series of splicing events. In this paper, we report the finding of a novel
doubly spliced Px MRNA in two out of eight HTLV-1-infected cell lines and in one out of 13 peripher-
al blood mononuclear cells from HTLV-1-infected individuals. The second splicing for this novel Px
MRNA is different from that for the known doubly spliced Px MRNA. A novel acceptor site in this
splicing was generated by a single point mutation (G to A) at nucleotide 7,337 of the Px gene...
Added Keywords: RESEARCH ARTICLE; MESSENGER RNA; SPLICING; P25REX CYTOPLASMIC
P H O S P H O P R O T E I N
Major Concept Codes: *15006 Blood, Blood-Forming Organs and Body Fluids-Blood, Lymphatic and
Reticuloendothelial Pathologies
*15008 Blood, Blood-Forming Organs and Body Fluids-Lymphatic Tissue and Reticuloendothelial
S y s t e m
*24010 Neoplasms and Neoplastic Agents-Blood and Reticuloendothelial Neoplasms
*31500 Genetics of Bacteria and Viruses
*33506 Virology-Animal Host Viruses
*36006 Medical and Clinical Microbiology-Virology
Minor Concept Codes: 10062 Biochemical Studies-Nucleic Acids, Purines and Pyrimidines
10064 Biochemical Studies-Proteins, Peptides and Amino Acids
Biosystematic Codes: 02623 Retroviridae (1993- )
86215 Hominidae
Super Taxonomic Groups: Microorganisms; Viruses; Animals; Chordates; Vertebrates; Mammals;
Primates; Humans
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