Sample BA on CD Record
TI:
Renal interstitial expansion in insulin-dependent diabetes mellitus.
AU: Lane-P-H; Steffes-M-W; Fioretto-P; Mauer-S-M
CS: Pediatric Nephrol., Cardinal Glennon Child. Hosp., 1465 S. Grand
Blvd., St. Louis, MO 63104, USA
SO: Kidney International 43(3): 661-667
SN: 0085-2538
PY: 1993
LA: English
AB: Eighty-four patients with insulin-dependent diabetes mellitus had
studies of renal function and quantitative renal morphometry
including mesangial volume fraction (Vvms/glom), index of
arteriolar hyalinosis, percentage of globally sclerosed glomeruli
(%GS), and interstitial volume fraction for total renal cortex
(Vvint/T). There was significant correlation among these four
parameters, and all four structural parameters correlated with
glomerular filtration rate and the log of urinary albumin excretion.
Stepwise multiple regression analysis showed that Vvmes/glom
and Vvint/T were additive, suggesting that they are partially
independent. Arteriolar hyalinosis and %GS did not improve the
correlations further. We hypothesized that Vvmes/glom, Vvint/T,
arteriolar hyalinosis, and %GS represent multiple but probably
interrelated pathologic mechanisms leading to the functional
disturbances of diabetic nephropathy. Longitudinal studies of
patients with diabetes and studies of patients with diseases
producing interstitial expansion in the absence of glomerular
disease may help clarify the independent role of interstitial
expansion in the kidney disease of diabetes mellitus.
DE: HUMAN; ARTERIOLAR HYALINOSIS; SCLEROSED GLOMERULI;
GLOMERULAR FILTRATION RATE
CC: CC12508 (Pathology-General-and-Miscellaneous-Inflammation-
and Inflammatory-Disease);
CC13004 (Metabolism-Carbohydrates);
CC13020 (Metabolism-Metabolic-Disorders);
CC14508 (Cardiovascular-System-Blood-Vessel-Pathology);
CC15504 (Urinary-System-and-External-Secretions-Physiology-
and-Biochemistry);
CC15506 (Urinary-System-and-External-Secretions-Pathology);
CC17008 (Endocrine-System-Pancreas)
CC: CC10064 (Biochemical-Studies-Proteins-Peptides-and-Amino-
Acids);
CC10068 (Biochemical-Studies-Carbohydrates);
CC13012 (Metabolism-Proteins-Peptides-and-Amino-Acids)
BC: BC86215 Hominidae
ST: Animals; Chordates; Vertebrates; Mammals; Primates; Humans
JA:
Biological Abstracts Vol. 095 Iss. 010 Ref. 115283.
UD: 9302
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