Biosis BA 998 Page 9
An Abstract
S a m p l e e n t r i e s f o u n d
i n
B A a n d B A / R R M
SAMPLE ABSTRACT
NEURAL COORDINATION
NERVOUS SYSTEM
9890. Murphy, Geoffrey G. and David L. Glanzman*. 1997. Science
278(5337): 467-471. Mediation of classical conditioning in Aplysia
californica by long-term potentiation of sensorimotor synapses.--
Long-term potentiation (LTP) is considered an important neuronal
mechanism of learning and memory. Currently, however, there is no
direct experimental link between LTP of an identified synapse and
learning. A cellular analog of classical conditioning in Aplysia was used
to determine whether this form of invertebrate learning involves N-
methyl-D-aspartate (NMDA)-type LTP. The NMDA receptor-antagonist
DL-2-amino-5-phosphonovalerate significantly disrupted synaptic en-
hancement after associative training but did not disrupt synaptic en-
hancement after nonassociative training. Thus, classical conditioning
in Aplysia appears to be mediated, in part, by LTP due to activation of
NMDA-related receptors.
*
Department of Physiological Science and Brain Research Institute, University of
California, 2859 Slichter Hall, Los Angeles, CA 90095-1568, USA.
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S a m p l e e n t r i e s f o u n d i n B A a n d B A / R R M
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