group _ (0.14±0.04, 0.20±0.04,and 0.34±0.05) and group _ (0.13±0.02, 0.15±0.03, and
0.23±0.04), and the difference between values of group _ and group _ was no significant._ While
breathing 100% O2, the VE/SaO2 values were significantly lower compared with those during
room air breathing in all the three groups. Conclusion The results suggested that hypoxic
ventilatory responses in migrators from low to high altitude for 20_80 days was more sensitive
than that in migrators resided for more than 3 years and native highlanders. Ventilation while
breathing 100% O2 was depressed at high altitude in all the subjects.
209.
THE INFLUENCE OF NEUROPEPTIDES AND NOREPINEPHRINE ON THE
HYPOTHALAMIC GONADOTROPIN-RELEASING HORMONE OF RATS EXPOSED TO
ACUTE HYPOXIA. Xiaojun Shi
1
, Jizhen Du
2
, Huitian Yu
3
, Tianyi Wu
4
. Life Scinces Division,
Graduate School at Shenzhen, Tainghua University
1
, Life Scineces Division, Zhejiang
University
2
, Depi. Neurosurgery Baoan, Hospital, Guandong
3
, High Alt. Med. Res. Inst. Qinghai,
PRC
4
.
The effects of hypoxia on hypothalamic-pituitary-gonadal (HPG)-axis and the modulating
mechanism has not been detailed. This study investigated the changes both of the hypothalamic
gonadotropin-releasing hormone (GnRH) and the plasma testosterone (T), response to acute
hypoxia in rats with the role of the arginine vasopressin (AVP) and corticotropin releasing
factor(CRF) and neurotransmitter in modulating this response to reveal the mechanisms by which
the reproductive endocrine functions of the rats adjusted to acute hypoxia. The rats were
subjected to acute hypoxia at a simulated altitude of 7000 m for 120 min and treated with AVP
and antagonist (DPArg), CRF and antiserum, or treated with norepinephrine (NE), reserpine and
prazosin respectively. It was showed that the levels of hypothalamic GnRH decreased after acute
hypoxia exposure(P<0.01) with increasing plasma T(P<0.01).Meantime, extraneous AVP
inhibited the secretion of hypothalamic GnRH and without remarkable changes treated by AVP
antagonist (DPArg). The levels of hypothalamic GnRH elevated significantly by icv NE(P<0.01).
Administration of reserpine and prazosin appeared a decreasing and increasing tendency on the
levels of hypothalamic GnRH, respectively. By contrast, icv propranolol reduced hypothalamic
GnRH contents. Thus concluded that acute hypoxia stimulated the secretion of hypothalamic
GnRH. Neuropeptide CRF and AVP suppress this secretive process. centrally icv CRF induces a
inhibition on the secretion of plasma T. NE is involved in the effect of hypoxia on the hormone
levels of HPG-axis mediated by b-adrenergic receptor and a-adrenergic receptor, which played a
role in hypoxic stress
210.
STUDY OF PATHOGENESIS OF ACUTE HIGH ALTITUDE SICKNESS AND SIRS. Zhang
Shifan
1
, Zhang Dehai
1
, Gao Wei
1
, Liu Huiping
1
, Zhu Yunkui
2
, Lu Wensheng
3
, Liu Chuanlan
4
.
Department of Thoracic Cardiovas Surgery, Lanzhou General Hospital of PLA
1
, Department of
Respiratory medicine, Lanzhou General Hospital of PLA
2
, Department of Thoracic Cardiovas
Surgery, the Second Affiliated Hospital of Lanzhou Medical College
3
, ICU Center, Lanzhou
General Hospital of PLA
4
.
Objective: To study the characteristic, pathogenesis and the relationship of acute high altitude
sickness(AHAS) and SIRS at high altitude. Methods: 1.The animal models of acute lung
injury(ALI) induced by endotoxin were established to compare pulmonary hemodynamics,
arterial blood-gas analysis, lung lymph flow(QL), pulmonary permeability surface area(PS) and
the ratio of lung lymphatic and plasma protein(L/P) between the group of highland (AG, n=5) and
flatland (FG, n=7). 2.Through reviewing and analyzing retrospectively the similar critical severe
cases in ICU in plain areas (Shanghai and Xi,an, altitude 5-300m) and moderate high altitude
areas (Lanzhou and Xining, altitude 1517-2661m), the scores of SIRS and MODS were carried
out to compare the differences of the functional parameters of organs or systems and the ending at
different altitude. Results: 1. The results of the ALI animal experiment revealed that there were
marked difference between the pulmonary arterial pressure (PAP), pulmonary wedge pressure
(PWP), QL, PS and L/P at highland and that on pain (P<0.01). 2. The research of clinical ICU
