204.
CLINICAL REVIEW OF ACUTE MOUNTAIN SICKNESS. Jun Seok SEO
1
, Yun Jeong KIM
1
,
Jae Myung CHUNG
1
. Kyungpook National University Hospital, DAEGU, Republic of KOREA
1
.
Background We refer the world of today as a global village and with increasing number of
traveler enjoying variety of sports such as hiking and skiing, and they are exposed in different and
higher altitudes compare to where they are living. For this reason, importance of high altitude
illness from changes in physiology and its effect has become greater than ever. Methods We
studied 13 college students who climbed Mt. Cholatse during 16th Dec, 2001 to 8th Jan. 2002,
and measured vital signs and changes of self aware symptoms during the climbing. Blood
pressure, respiratory rate, O2 saturation rate, and pulse rates are checked using pulse oxymeter.
Evaluation of self aware symptos are analysed using self questioneer method. Results The
syndrome of high-altitude illness represents a broad spectrums of clinical conditions that range
from mild to life-threatening conditions. The incidence of high-altitude illness depends on many
variables. The rate of ascent, final altitude reached, and duration of stay at any altitude and
individual susceptibility. Gender does not affect the incidence of acute mountain sickness.
Conclusion High altitude illness is a series of clinical syndrome with a great diversity to each
encountered individuals, and there is no significant relationship between the severity of symptom
to changes in oxygen saturation curve in different altitude. For this reason, high altitude mountain
climber should keep in mind of this fact and prepare to prevent the illness, and when the
symptoms develop, a rapid counter measures should be made.
205.
INTER-INDIVIDUAL VARIATIONS TO HYPOXIA: MECHANISMS AND APPLICATIONS.
Tatiana Serebrovskaya
1
, R. James Swanson
2
. Bogomoletz Institute of Physiology, Kiev, Ukraine
1
,
Old Dominion University, Norfolk, VA
2
.
Individual homeostatic response variation to hypoxia has been confirmed by investigations in
the USSR and CIS. The proven influence of both hereditary and environmental parameters on
physiological responses must drive the selection of individual regimes for athletic training,
disease treatment and outcome prognostication. Our longitudinal examinations of identical twins
both at sea level and altitudes have shown that the ventilatory response to hypoxic stimulus is a
rigid, genetically determined, physiological characteristic reflecting an organism's overall non-
specific reactivity. On the basis of our twin investigations, we have designed a nomogram to
estimate individual non-specific reactivity and functional reserves for prognosis of subject
adaptation to hypoxia. Different strategies of adaptation were marked out in persons with
different hypoxic ventilatory sensitivity. Intermittent hypoxic training (IHT) regimes can be
customized to match this known individual reactivity. Mechanisms that mediate inter-individual
variation of adaptation to hypoxia were determined mostly by making measurements in animals
with high (HR) and low (LR) resistance to acute hypoxia. Although there are several possible
causes for such variation, much of the interest in the CIS has focused on the mitochondria. CIS
researchers found HR rats, when compared to LR rats, to have greater mitochondrial enzyme
complex I activity, increased nitric oxide inhibition of __2+-ATPase activity with concomitant
decreased intracellular __2+, enhanced antioxidant activity and increased gene expression.
Differential selective oxidation of two Krebs cycle substrates, alpha-ketoglutarate versus
succinate, acts more intensively in HR animals enhancing cholinergic status. Our investigations
have shown that L-arginine injections as well as IHT increase mitochondrial calcium capacity in
LR rats to the same level as HR rats. Different effects of mitochondrial ATP-dependent
potassium channel openers upon mytochondrial respiration in HR and LR was found. These
effects seem to be similar to effects of IHT.
206.
THE EFFECT OF PULMONARY HYPERTENSION ON MYOCARDIAL INJURY DURING
INTRACARDIAC PROCEDURES AT HIGH ALTITUDE . Zhang Sheng-Tian
1
, Li Su-Zhi
1
,
Chen Zhong-Dong
1
. The Center of High Altitude Medicine PLA, the Military General Hospital of
Tibet, Lhasa, R. P
1
.
