The goal of this study was to explore the correlation between pulmonary function at sea level
and the incidence of Acute Mountain Sickness (AMS) after ascending to high altitude. Methods:
The pulmonary function of 113 men aged 19±1 years was tested using _max229D spirometer at
sea level. Two days later after they traveled to Lhasa (3658m altitude) by airplane, the men's
pulmonary function was tested again and symptomatic scores of AMS were evaluated. Then the
correlations between low altitude and high altitude pulmonary function were analyzed. Results: It
was found that the peak expiratory flow (PEF) and forced expiratory volume in 1s (FEV1.0) was
obviously smaller in subjects who developed AMS than subjects doing well. There were obvious
reverse correlations between the symptomatic scores of AMS and PEF, FEV1.0. Reverse
correlation between the AMS scores and the forced vital capacity also existed. It was indicated
the better the pulmonary function at low altitude_the less incidence of AMS at high altitude.
Conclusion: Testing pulmonary function at sea level could be used for prediction of AMS.
183.
THERAPEUTIC EFFECTS OF ANISODAMICS ON ACUTE HIGH ALTITUDE
PULMONARY EDEMA. Zhou Qi-quan
1
, Zhang Xue-feng
2
, Yang Jing-yi
1
, Li Ai-dong
1
, Zhou
Bo
3
. Chengdu Military Medical College of Third Military Medical University, Chengdu 6
1
008
3
China
1
, The people`s hospital of Golmud city, Qinghai
2
, The 25th Hospital of PLA, Jiuquan,
China
3
.
The goal of this study is to research the therapeutic effect and mechanism of anisodamics on
acute high altitude pulmonary edema (HAPE). The therapeutic effects of anisodamics and general
therapy on HAPE were observed at high altitude at the Mt. Tanggula and Mt. Kunlun road
construction sites (average altitude 4700m). 400 HAPE cases were randomly divided into two
groups. Anisodamics were used to treat one group (263 cases), and the general method was used
to treat the other group (137 cases). There was no remarkable difference in the distribution of age,
the degree of severity of HAPE, or the standard HAPE diagnosis between two groups. The group
treated with anisodamics was given anisodamice 20~40 mg/first dose by intramuscular injection
or venoclysis. Following administrations were given based on the severity of the HAPE at
15~30min intervals until the condition improved. The maximum dose of anisodamics
administered was 200mg. The group treated with the general method was given the same
therapeutic measures except without use of anisodamics. The results showed that aniaodamics
therapeutic effect was much better than general therapy. With anisodamics, the symptoms and
signs of pulmonary edema was shortened remarkably, the days of average hospitalization was
reduced remarkably, and the cure rate was raised remarkably. The therapeutic effect of the group
treated with anisodamics was higher than that of those treated by the general method, and the
differences between two groups were very significant (P<0.001). Before and after the treatment
of the HAPE patients, the observation of the hemodynamics of the two groups showed that all
indices in anisodamics treated group had changed remarkably execpt for pulse pressure (PP),
mean systolic pressare (MSP), mean diastolic pressare (MDP) and mean arterial pressare (MAP).
However, in the group treated with general therapy, there were no changes in all indices except
PP, MSP, MDP and MAP had decreased. We conclude that anisodamics are beneficial for
treatment of HAPE and the improvement of hemodynamics in HAPE patients and anisodmics
may be important for the treatment of HAPE.
184.
THE RELATIONSHIP BETWEEN HIGH ALTITUDE CEREBRAL EDEMA AND
MICROCIRCULATORY DISTURBANCE AS WELL ITS CLINIC RESCUE AND
TREATMANT. Zhou Qi-Quan
1
, Li Ai-Dong
1
, Zhang Xue-Feng
2
. Chengdu Medical College of
Third Military Medical University,Chengdu,China
1
, People's Hospital of Germu City, Qinghai
2
.
The goal of this study is to research the mechanisms of high altitude cerebral edema and to
provide methods for its prevention and cure. We observed the population of subjects living at
high altitude and performed animal tests. The observation of subjects who entered high altitude
regions at a high rate showed that their brain's blood stream mount were higher distinctly than
those lived in lower altitude areas. The brain's blood stream mount of acute mountain sickness
