160.
AMINOPHYLLINE PREVENTS THE PULMONARY PRESSURE REBOUND AFTER
WITHDRAWAL OF INHALED NO IN HAPE. Xinbing Mou
1
, Yuqi Gao
2
, Yufu Liu
2
, Ganglin
Ye
1
, Hongya Tang
1
. High Altitude Medical Research Center, The Military General Hospital of
Tibet, Tibet, China;
1
, Department of Pathophysiology and High Altitude Physiology, Third
Military Medical University, Chong
2
.
OBJECTIVE: To evaluate the Preventive effects of aminophylline on the rebound response
after withdrawal of inhaled nitric oxide in high altitude pulmonary edema (HAPE). METHODS:
Ten patients with HAPE inhaled NO for 30 minutes. In the same time of NO withdrawal,
aminophylline (0.25g, iv) was administered and patients return to breathe the room air. The
pulmonary arterial pressure was monitored continually via Swan-Ganz catheter and PaO2 were
measured. RESULTS: After nitric oxide inhalation, the mPAP of patients with HAPE
significantly decreased, the level of PaO2 increased obviously; when suddenly stopping NO
inhalation, followed by 30 minutes with room air, the decreased of mPAP became more and more
high, the level of the mPAP in 5 minutes was significantly higher than the baseline ( before NO
inhalation), the mPAP reached the peak in 10 minutes after NO withdrawl, and the PaO2 in this
time was also much lower than the values before NO inhalation. Administering aminophylline
while withdraw NO, although the decreased mPAP tended to recover, the speed of return of
pressure was slower than the control's, even in 30 minutes the mPAP was still lower than
baseline. CONCLUSION: NO inhalation reverses the pulmonary hypertension in HAPE, the
rebound reaction of sudden withdrawal NO existed in patients with HAPE, aminophylline has
preventive effects on the pulmonary pressure rebound reaction to withdrawal of NO inhalation in
patients with HAPE (By grant of 01L062).
161.
COMPARISON OF HYPOXIC PULMONARY PRESSURE RESPONSE BETWEEN NATIVE
TIBETANS AND IMMIGRANT HANS. Xinbing Mou
1
, Yuqi Gao
2
, Fuyu Liu
2
, Ganglin Ye
1
,
Hongya Tang
1
, Xiaobo Zhou
1
, Guanglin Cheng
1
. High Altitude Medical Research Center, The
Military General Hospital of Tibet, Tibet, China;
1
, Department of Pathophysiology and High
Altitude Physiology, Third Military Medical University, Chong
2
.
OBJECTIVE: To compare the characteristics of the hypoxic pulmonary hypertension (HPH),
hypoxic pulmonary pressure response (HPPR) between highland Native Tibetans and immigrant
Hans. METHODS: In Lhasa (3658m), the pulmonary hemodynamic parameters of 5 healthy
native Tibetans and 5 healthy immigrant Hans were measured at rest, breathing 100% O2 and
14%O2, respectively by right heart canulation. RESULTS: Resting mean pulmonary arterial
pressure (mPAP) of 5 Native Tibetans and 4 immigrant Hans was within sea-level norms, only
one immigrant Han showed hypoxic pulmonary hypertension. The mPAP of all highland natives
and immigrants were increased while subjects breathed a hypoxic gas mixture, but the mPAP of
Hans was increased significantly after breathing hypoxic gas for 1 minute, the mPAP of Natives
began to increase after breathing hypoxic gas for 3 minute.The mPAP of Natives was recovered
to basic level after subjects stopped breathing hypoxic gas 1 minutes. The mPAP of Hans was
returned to basicl level after subjects stopped breathing hypoxic gas 10 minutes. CONCLUSION:
Resting pulmonary arterial pressures of both are similar to sea-level values. Both of the well-
adapted native Tibetans and immigrant Hans have HPPR, however the HPPR of native Tibetans
is blunted (By grant of NSFC 39730190 and 30393131).
162.
RELATION BETWEEN TESTOSTERONE AND SOME PARAMETERS OF
ACCLIMATIZATION IN VOLUNTEERS SUBJECTED TO ACUTE EXPOSURE OF
ALTITUDE (HUANCAYO). Elydia Mujica
1
, Haydee Zúñiga
1
, Hugo Cebreros
1
, Javier Torres
1
,
José Aliaga
1
, Julio Huamán
1
, Sergio Ronceros
1
, Walter Ponciano
1
, Manuel Ortiz
1
, Michan
Malca
1
. Instituto Biología Andina. Fac. Medicina. Universidad Nacional Mayor de San Marcos.
Lima, Perú
1
.
