129.
THERAPEUTIC EFFECT OF RHODIOLA CRENULATA ON ACUTE HIGH-ALTITUDE
PULMONARY EDEMA. . Zhuang Lan-Ping
1
, Chen Wei-Jun
1
, Chen Yong
1
. Tibet Institute of
High Mountain Sickness and Cardiovascular Disease, Lhasa, R. P. China
1
.
Objective: To study the therapeutic effect of Rhodiola Crenulata (SLMB) on acute high-
altitude pulmonary edema (AHAPE). Methods: 151 subjects with AHAPE were enrolled in the
experimental group. The measurement of pulmonary pressure related time-indications including
right ventricular ejection time (RVET), right ventricular previous ejection period (RPEP) and
ascending time (AT) were taken by pulse Doppler echocardiography before the SLMB was given.
Plasma renin activity (PRA) was measured by radioimmunoassay (RIA) before and after the
administration of SLMB. 98 normal subjects with AHAPE were included in the control group,
which were treated by aminophylline. Results: Therapeutic effect of the studied group was better
than control group (P<0.001). It appeared that RVET and AT levels were increased, and rate of
RPEP/AT was decreased (P<0.01-0.05) after the treatment with SLMB. It was noticed that
arterial oxygen saturation was improved significantly. Conclusion: SLMB had beneficial effect
on AHAPE. It may be related to decreased pulmonary artery pressure and improve arterial
oxygen saturation. The drug might have inhibitory effects on catecholamine and calcium
channels.
130.
CHANGES IN RBC, HB AND HCT DURING LIVING HIGH-TRAINING LOW. Xiaoxia Li
1
,
Yang Hu
2
, Weiping Li
1
, Zhong Tian
1
. Department of Sport physiology, Shandong Physical
Education Institute
1
, Department of Sport and Human Sciences, Beijing Sport University,
2
.
Xiaoxia Li
1
, Yang Hu
2
, Weiping Li
1
, Zhong Tian
1
. Department of Sport physiology, Shandong
Physical Education Institute, Jinan
25
006
3
, China
1
, Department of Sport and Human Sciences,
Beijing Sport University, Beijing, China
2
.
In order to investigate the effects of hypoxic training on hematological indices and aerobic
performance, 28 college students were randomly divided into 4 groups, with 7 in each group: 1)
living high-training low group (HiLo); 2) living high sedentary group (HiS); 3) living low-
training low group (LoLo); and 4) living low sedentary group (LoS). HiLo and HiS were exposed
to hypobaric hypoxia (2,500 m simulated altitude) for 12 hours every day. HiLo and LoLo ran
3,000 m at sea level once everyday. HiS and LoS did not do any exercises during the experiment.
This protocol lasted for 4 weeks. The results showed that RBC, Hb and Hct increased at the
beginning of hypoxic exposure compared with the baseline, and reached a peak 19 days later.
EPO did not show any significant changes initially, but reached a significantly higher peak level
after 11 days. MCV did not change much throughout the experiment. VO2max increased in HiLo
and HiS compared with that before hypoxia exposure, but not in LoLo and LoS. 3000m running
improved the most in the HiLo group. Our study indicated that intermittent hypoxia training
could increase RBC, Hb, Hct, serum erythropoietin, VO2max and 3,000 running performance.
131.
GENISTEIN PREVENTS HYPOXIC PULMONARY VASCULAR REMODELING. Xiaoli Li
1
,
Yuqi Gao
1
, Fuyu Liu
1
, Chunhua Jiang
1
, Dekun Xiang
1
, Qingyuan Huang
1
. Department of
Pathophysiology and High Altitude Physiology, Third Military Medical University, Chong
1
.
Objective: To study the effects of genistein on interfering with pulmonary vascular structural
remodeling induced by chronic hypoxia and its mechanisms. Methods: Male Wistar rats were
randomly divided into control group (C), hypoxia group (H) and hypoxia with genistein group
(H+G). Pulmonary vascular microstructure was measured. The expression of proliferating cell
nuclear antigen (PCNA) in pulmonary arteries was detected using immunohistochemistry
techique. Results: The walls of small pulmonary blood vessels were significantly thicker in
hypoxic group than in control group(P<0.01). The percentage of muscularized arteries in small
pulmonary vessels of rats in hypoxic group was significantly larger than in control group
(P<0.01). The walls of small pulmonary blood vessels were significantly thinner in genistein
supplementation group than in hypoxic group (P<0.01), there was no significant difference
