115.
RISE OF BODY TEMPERATURE DURING THE PROCESS OF HIGH ALTITUDE
ACCLIMATIZATION. Norihiro Kamikomaki
1
, Osamu Nishioka
2
. Rosai Hospital for silicosis
1
,
Rosai Hospital for Silicosis
2
.
Rise of body temperature during the process of high altitude acclimatization Background.
Low-grade fever occurs sometimes at high altitude. We analyzed the relationship between
altitude of stay, AMS score, oxygen saturation (SpO2) and body temperature. Methods. The
subjects were members of the expedition team to Muztagh Ata. We recorded the modified Lake
Louise AMS score, measured SpO2 and axillary temperature during mountain climbing. We
analyzed the relationship between altitude of stay, AMS score, SpO2 and body temperature of
three members (A-C) of the second Attack team to the south peak. Results. Altitude: m, AMS
score: points, SpO2: %, BT: degrees Fahrenheit Conclusions. Body temperature tended to be
higher when AMS score rose and SpO2 decreased. The O2 dissociation curve shifts to the right
when temperature rises, and release of O2 to peripheral tissue is promoted. Therefore, the rise in
body temperature is thought to be suitable for acclimatization.
116.
EXPRESSION OF MACROPHAGE INFLAMMATORY PROTEIN IN HIGH ALTITUDE
POLYCYTHEMIA. Chai Ke-Xia
1
, Jia Nai-Yong
1
, Li Zhan-Quan
1
, Cui Sen
1
, Yang Fa-Man
1
, Luo
Wei
1
, Li Yu-Li
1
, Li Xue-Mei
1
. Qinghai Medical College Hospital, Xining, Qinghai, P.R. China.
1
.
The incidence of high altitude polycythemia (HAPC) is directly related to environmental
factors, such as elevation, hypoxia, and low atmospheric pressure. Its mechanism is very
complicated. A great deal of past study defined it as erythroblast proliferative disease. This study
explores the correlation between chemokine and HAPC by examining the concentrations of
plasma Macrophage Inflammatory Protein-1_ (MIP-1_). Methods: The concentrations of plasma
MIP-1_ in patients with HAPC, both natives and Han immigrants living at altitude of 4300m for
different period (<1years group, 1-5 years group, 6 years group), were assessed by solid phase
sandwich enzyme-linked-immunosorbent assay (ELISA). The results were compared with the
MIP-1_ plasma concentration in healthy natives living at altitude of 2260m (Xining). Results:
The concentrations of plasma MIP-1_ in patients with HAPC were 31.6±5.2pg/ml and were
significantly higher than that of the healthy Xining natives (24.5±4.3pg/ml [P<0.01]). The
concentrations of plasma MIP-1_ of the HAPC patients living at high altitude for less than 1 year
group (31.7±7.2pg/ml) and between 1 and 5 years (35.3±10.5pg/ml) were significantly higher
than that of the healthy Xining natives (24.5±4.3pg/ml [P<0.01]). There was a highly positive
correlation between plasma MIP-1_ and hemoglobin levels(r=0.634). Conclusion: These results
show that MIP-1_ is a participant in the pathology process of HAPC .The increase of MIP-1_ in
patients with HAPC may be a protective mechanism against chronic mountain sickness, having
an important function in postponing the development of HAPC.
117.
LEFT VENTRICULAR DIASTOLIC FUNCTION IN HIGHLANDERS WITH ESSENTIAL
HYPERTENSION. Tatyana Khan
1
, Abdirashid Maripov
1
, Akyl Sydykov
1
, Akpay Sarybaev
1
.
National Centre of Cardiology and Internal Medicine, Bishkek, Kyrgyzstan
1
.
Left ventricular diastolic dysfunction (LVDD) is common in essential hypertension (EH).
LVDD has been reported in pulmonary hypertension (PH). The aim of the study was to
investigate left ventricular diastolic function in highlanders (HL) with EH in high altitude
hypoxic environment. Subjects - 10 HL with EH (mean age 54±2,6 yrs), residing at altitudes of
2900-3600m. 26 age matched HL serve as control. They were divided into 2 groups: 15HL with
PH (PAPmean25mm Hg) and 11HL without PH (PAPmean<25 mm Hg). All investigations were
performed at altitude of 3000m. Pulmonary hemodynamics and diastolic function were evaluated
by 2-dimensional and Doppler echocardiography.
1. Without PH
2. EH
3. PH
P1-
2<
P1
-3<
P2-
3<
