result of the study showed that HPT in HAPC decreased with increasing hemoglobin levels. This
phenomenon requires further investigation.
111.
EFFECT OF HYPOXIA TEST ON HUMAN HEART RATE AND OXYGEN SATURATION.
Chen Juan
1
, Xiao Hua-Jun
1
, Qin Zhi-Feng
1
. Institute of Aviation Medicine, Air Force, Beijing,
China
1
.
When the plain settling people come into tableland in short time, the depression of oxygen
partial pressure will make physiological function of human body change in many fields. In order
to keep people who come into tableland healthy, so it is important for them to have hypoxia
tolerance examination. In the past years, we usually screened the subject by 5 000m hypoxia
tolerance examination. By this way, the subject was set into hypobaric chamber and underwent
simulated altitude of 5 000m for 30 min. Another method is to simulate hypoxia tolerance
examination at 5 000m altitude by oxygen-nitrogen mixer. But the scope of the two methods was
limited. So it is necessary to explore a new method. The present study was designed to explore a
new method of hypoxia tolerance examination to select people who will come into tableland.
Twenty healthy male subjects seated in hypobaric chamber separately, inhaling air in the ground
for control, then they were exposed to 4 000m, 5 000m, 6 000m and 7 100m separately, and each
altitude for 10 min. Heart rate, oxygen saturation (SaO2) level and electrocardiogram was
recorded per 5min, and the symptom changes of subjects were observed and recorded.3 of 20
were unable to pass the hypoxia tolerance examination because of their pale complexion, cold
sweat and abnormal physiological index. Their examination was terminated immediately as soon
as abnormal index coming. And after breathing 100% oxygen, all of their abnormal index got
back. The other 17 subjects were able to pass the hypoxia tolerance examination at
4100~7100m.Their cognitive ability, consciousness and symptom are normal. The new hypoxia
tolerance examination method was effective by practice. The heart rate raised with the attitude
rising and the blood saturation level decreased gradually with the attitude rising. But the blood
saturation level was different greatly for each subject. So the blood saturation level was only a
subordinate index for the hypoxia tolerance examination.
112.
CHANGES OF ADRENOMEDULLIN IN PLASMA OF PULMONARY CIRCULATION
AND IN THE EXTRACTS OF LUNG OF CHRONIC HYPOXIC RATS. Du Jun-Ying
1
, Zuo
Hui
1
, Feng Tian-Kai
1
. Department of Pathology, Bethune Military Medical College,
Shijiazhuang, China
1
.
Objective: To explore the pathophysiological role of adrenomedullin(ADM) in mechanism of
hypoxic pulmonary hypertension(HPH),we investigated the content changes of ADM in plasma
of pulmonary artery(PA) and thoracic aorta(TA) and in extractives of lung in pulmonary
hypertensive rats exposure to chronic hypoxia and its relationship with HPH and morphometrics.
Methods: 24 adult male Sprague-Dawley rats were randomly divided into 4 groups (n=6):
control, chronic intermittent normobaric hypoxia(CINH,10% oxygen,8hour/day, 7day/week) 1
week, CINH 2 week and CINH 3 week. The contents of ADM in plasma and extractives of lung
tissues were determined by specific radio-immunoassay. The changes of pulmonary artery
pressure (PAP) and right heart hypertrophy indexes(RHHI) were monitored simultaneously. The
lung morphological indices,such as density on muscularized pulmonary arteriole(DMPA), percent
of tunica media acreage (PTMA) and counts of smooth muscle cells(CSMC) in wall of small
pulmonary arteriolae were examined by light microscopes and morphometrics analysis. Results:
Compared with control, PAP and RHHI and DMPA and PTMA of hypoxic rats were significantly
increased along with prolonging the time of exposure to CINH (P<0.01). CSMC in CINH 2 and 3
week were significantly higher than that in control, but CSMC in CINH 3 week were significantly
lower than that in CINH 2 week (P<0.05). In addition, hyaline degeneration in wall of small
pulmonary arteriolae and arterial hyperemia and inflammation cell infiltration in the lung tissues
in CINH 2 and 3 week were observed simultaneously. In control, the levels of ADM in plasma of
PA were significantly higher than that of TA (P<0.01). Compared with control, ADM contents in
