artery diameter (RPAD) by chest X-ray, blood pressure (BP), body mass index (BMI), waist
circumference (WC),waist/hip circumference ratio (WHR) and history of smoking (HS). 32 of the
residents belong to a cluster of CMS and were studied by cluster analysis according to Hgb, Hct,
and RPAD. The other 45 non-CMS subjects made up the control group. Results: .The clinical
characteristic of classification are shown in Table 1.
CMS
CONTROL
Hgb(gm/100ml)21.14±3.20** 15.94±1.82
Hct(%)
73±10**
51±7
RPAD(cm)
1.76±0.27**
1.40±0.22
BMI(Kg/m2)
27.10±3.53*
24.86±4.98
WHR
0.93±0.05**
0.88±0.05
WC(cm)
96.63±11.46** 86.84±10.58
*p<0.05 **p<0.001 Two groups contained the following dependent variables: age, sex, and
race, BP, WC, BMI, WHR, FPG and H. S. The independent variables, Hgb, Hct, and RPAD,
were entered into logistic regression analysis. This analysis indicated that the probability (P) of
CMS increased as WHR increased. The equation utilized for this analysis is as follows: P=1/
[1+exp (23.0007-24.9883**WHR)], (**p<0.001) Conclusion: The results suggest that abdominal
obesity is a risk factor for the development of CMS at high altitude.
105.
TGF-BETA1, NO AND ET ARE ASSOCIATED WITH CHRONIC MOUNTAIN SICKNESS.
Gao Ji-Dong
1
, Dai Qing-Xiang
1
, Zhan Xiao-Yan
1
, Yang Qing-Yan
1
, Xu Hui-Ning
1
, Xiao Hui-
Ning
1
, Ge Lei
2
. Qinghai Medical College Hospital, Xining, Qinghai, P.R. China.
1
, Qinghai
Medical College Hospital, Xining, Qinghai, P.R. China.
2
.
Some cytokines such as transforming growth factor-_1(TGF-_1), nitric oxide (NO) and
endothelin (ET) have been implicated in the pathogenesis of hypoxia-induced pulmonary
hypertension. The aims of this study were to investigate the association of TGF-_1, NO and ET
with chronic mountain sickness (CMS). Methods: 34 Tibetan and 27 Han residents aged 25--73
years (51 male and 10 female) were investigated at altitude of 3702m in Qinghai province. The
mean duration living at this altitude was 37.77±18.66 years. Fasting serum TGF-_1 (ELISA), NO
(colorimetry), plasma ET (RIA), hemoglobin (Hgb), hematocrit (Hct), right pulmonary artery
diameter (RPAD) by X-ray, plasma glucose (FPG), blood pressure (BP), body mass index (BMI),
and history of smoking (HS) were collected in 2002. 25 residents were diagnosed with CMS g to
Hgb, Hct, and RPAD. The other residents served as the control group. Results: Serum TGF-_1
was significantly increased in CMS as is shown in Table 1:
CMS
Control
Hgb(gm/100ml) 21.53±3.3**
16.05±1.72
Hct(%)
71±8 **
52±7
RPAD(cm)
1.79±0.27**
1.39±0.21
NO(µmol/L)
37.61±23.90
45.56±21.85
ET(pg/ml)
46.14±28.39
37.36±27.69
TGF-_1(ng/ml)
19.16±7.43*
13.81±6.66
* p<0.01 ** p<0.001
CMS or control were considered as the dependent variable and TGF-_1,NO, ET and other
factors (Xi) including age, sex, race, BP, BMI, FPG,HS as independent variables were entered
into logistic regression analysis.The probability (P) for CMS development was as follows: p=1/
{1+ exp (7.275-0.263*TGF-_1+0.059*NO+0.005ET+_iXi)}, (*p<0.05) Conclusions: The
results suggest that the increasing TGF-_1 and decreasing NO at high altitude may, at least in
part, be associated with the development of CMS.
106.
TIBETAN MEDICINE ----THE ANGEL OF HEALTHY TIBETAN . Duo Jie
1
. Qinghai Tibetan
Medicine Research Institute
1
.
