HR (1) YS(2)
HR YS
HR YS
10
2260
3400
4600
5020
102.4±2.6 3.36±0.28
100.1±6.8 3.47±0.40
106.2±10.2 3.09±0.58
111.0±6.2** 3.95±0.38**
97.2±4.3 3.15±0.37
97.7±6.8 3.11±0.38
101.0±7.8 2.41±0.55
102.9±6.0* 3.26±055**
113.8±3.2** 3.19±0.17
78.4±3.6 1.35±0.10
83.2±6.3 1.59±0.22*
89.3±3.5 ** 1.29±0.19
101.2±7.9 ** 1.37±0.21
105.0±9.1** 1.28±0.16
Heart rate: times/min.;
(2)
Energy metabolic rate under standard state: kilo
karat/min./m2 Compared with that of sea level *P<0.01 ** P<0.001 Labor Time Rate (%): at
altitude of 10, 2,260, 3,400, 4,600 and 5,020 meters. Roadbed leveling: 79.58 64.16 51.25 49.58
36.25 Earth excavating: 77.19 65.86 52.70 48.75 37.08 1. Changes vary from job to job. For the
type of work that requires single action volume, constant work volume and low energy
consumption at an altitude of above 3,400m, the energy metabolic rate and heart rate exhibit a
significant rise. Conversely, an increase in altitude is accompanied by a progressive decrease in
labor time rate. 2. Given the same labor intensity, the pulmonary ventilation volume rises with the
increase in altitude and the pure labor time is inversely proportional to the altitude. Conclusion:
For construction at high altitudes, production quota, means of labor, and time ratio of labor/rest
should be arranged according to the types of work as well as the altitudes.
94.
THE EFFECTS OF ATRIAL NATRIURETIC PEPTIDE ON HAPE. Yang Hu-Ming
1
, Du Buo-
Yu
1
, Wang Yu-Yin
2
. Emergency Department, The First Hospital of Xining city Xining City,
Qinghai China
1
, Emergency Department, The First Hospital of Xining city Xining City, Qinghai
China
2
.
Atrial Natriuretic Peptide (ANP) can adjust pulmonary vascular tone and the content of
pulmonary surfactant as well as produce natriuresis, diuresis and vasodilatation. Changes of ANP
in high altitude pulmonary edema (HAPE) and normal subjects are discussed in this paper.
Methods: Normal subjects at different altitudes were divided into a lowland (n=19; 31m), a
moderate altitude (n=19; 2260m) and a high altitude (n=18; 3719m) group. The patients with
HAPE (n=16) at an altitude of 4100m) were selected as the HAPE group. Results: The ANP of
the normal subjects in moderate and high altitude groups were remarkably higher than that in
lowland (747.9±130.5pg/L, 632.8±107.4pg/L, and 166.7±80.2), and was much higher in the
HAPE groups (1178.8±383.0pg/L). Conclusions: These finding suggest that the level of ANP in
normal high altitude residents and HAPE was significantly higher than that in lowlanders, which
suggests that overproduction of ANP at high altitudes may play an important role in the
physiological acclimatization in normal subjects and in the pathophysiology of HAPE.
95.
HORMONAL AND PULMONARY CHANGES DURING ACUTE AND PROLONGED
EXPOSURE TO HYPOBARIC HYPOXIA. Mazhar Hussain
1
, Muhammad Aslam
1
. Army
Medical College, Rawalpindi, Pakistan
1
.
The hormonal and pulmonary changes during acute and prolonged exposure to hypobaric
hypoxia were analysed in forty four lowlander adult males. Twenty four non-acclimatised healthy
males were subgrouped into four groups, each taking placebo or acetazolamide (250 mg) or
dexamethasone (4 mg) or both twice daily for five days commencing 24 hours before ascent. The
volunteers reached altitude (4578 meters) within one day. The second group (n=24) was
comprised of volunteers who had stayed 4 and 8 weeks at the same altitude. Their altitude
sickness symptoms were recorded after 24 and 72 hours of acute ascent. Arterial PO2, SO2,
PCO2, pH, HCO-3 Na+, K+, iCa++ and Hct were measured by blood gas-electrolyte analyzer
(Mallincrodt, USA). Expiratory spirometry was done by compact spirometer (vitalograph). Sera
of volunteers were transported in liquid nitrogen to Rawalpindi for the measurement of
erythropoietin, ACTH, TSH, FT4, cortisol, and aldosterone by radioimmunoassay. The reduction
in FVC, %FEV1, PEF, FEF2575% and MVV was recorded after 24 hours of acute ascent, which
increased to pre-ascent level in volunteers with 8 weeks of stay at altitude. A greater increase in
