RBC aggregated and increased moderately (P<0.01). All parameters recovered after the test.
Conclusions We conclude that the change of BP is related to the diameters of venule and
arteriole, and also to the aggregation of erythrocytes. The change improves the blood vessel
conformity and heart function. and is a physiological regulation to compensate and adapt the
circumstances. It also showed that staying in the low pressure cabin at an imitate altitude of five
thousand meters is beneficial to cardiovascular function. This method will also provide a
theoretical basis for the treatment to coronary heart disease and hypertension at high plateau.
268.
EFFECT OF LISHUKANG ON ERYTHROCYTE BIOPHYSICAL PROPERTIES IN
PATIENTS WITH POLYCYTHEMIA AT HIGH ALTITUDE. Zhang Xin-Sheng
1
, Xi Ai-Qi
1
.
Geriatric Department of Qinghai PeopleHospital, Xining, Qinghai, P.R.China
1
.
To observe the effect of Lishukang capsules on the metabolism of free radicals, including
superoxide dismutase (SOD), glutathionperoxide (GSH--Px), malondialdehyde (MDA), nitrogen
oxide synthase (NOS) and the erythrocyte filtration index (EIF) in patients with high altitude
polycythemia (HAPC). Methods: 102 cases of HAPC at high altitude (3300m) were selected and
the activity of RBC-SOD and GSH--Px, the level of MDA, NOS and EIF were measured before
and after taking Lishukang capsules. Results: Lishukang significantly increased the activities of
RBC- SOD, GSH--PX and NOS (P<0.0l) and decrease the level of MDA and EIF (P<0.0l) in
patients with HAPC. Conclusions: Lishukang can improve and modulate the metabolism of free
radicals, increase erythrocyte deformability and increase the activity of NOS in HAPC and may
be valuable in the prevention and treatment of HAPC.
269.
CHANGE OF b-ENDORPHIN CONTENT IN ARTERIES AFTER RAPID ASCENT TO HIGH
ALTITUDE. Feng Xi-Ying
1
. Dept. of Respiratory Medicine, Qinghai Medical College Hospital,
Xining, Qinghai, P.R. China
1
.
_-endorphin (_-EP) is one of the endogenous opium peptides (EOP) is a source of Pro-
opiomelanocortin (POMC). _-EP is released under in a response to various types of stress and can
inhibit breathing. This research is to discuss the change in serum _-endorphin (_-EP) content in
healthy young men who ascend rapidly to high altitude .Methods The serum _-EP content of 40
men (age 19±2 yr.) from low altitude was measured by Radioimmunoassay (RIA) in moderate
(2,260m) and high altitudes (3,780m) on the first day, 5th days and 15th days at high altitude.
Results The serum _-EP content were increased on the first day and reached it are the peak on the
5th day. By the 15th day, the serum _-EP content was decreased. There was a significant
difference between serum _-EP content on the 5th days in high and moderate altitude and
between 15th days in high and 5th days in high altitude (P<0.01-0.001). Conclusion There results
suggest that the release of large amounts _-EP after rapid ascent to high altitude from low altitude
is a stress reaction of humans to hypoxia and facilitates acclimatization of humans to high
altitude.
270.
NOCTURNAL OXYGEN ENRICHMENT OF ROOM AIR IN SLEEP APNEA AND OXYGEN
SATURATION AT 5380M ALTITUDE. Zhang Xi-Zhou
1
, Zheng Yan-An
1
, Cui Jia-Hua
1
. The
18th Hospital of PLA, Yecheng, Xinjiang
1
.
The goal of this study is to document the effect of oxygen-enrichment on sleep apnoea (SA)
and arterial oxygen saturation (SaO2) at high altitude. Method: Room air was enriched with
oxygen by 26-27 at 5380m altitude. Five subjects slept in the oxygen-enriched atmosphere and
their pulse, respiratory movement, and SaO2 were monitored. Results: With oxygen enrichment,
the subjects had a greater increase in SaO2 (p<0.001) and no apnea, but while sleeping in ambient
air, four males had frequent sleep apnea (2,34,20,39 times per 30 min, mean time
8.7s).Conclusion: Oxygen enrichment of room air at high altitude shows great promise for
improving sleep quality.
