20 samples of bone marrow tissue in patients with HAPC were collected at Maduo county,
Guoluo prefecture (4300m). Samples from 10 patients with without HAPC were collected in
Xining (2260m) to be used as a control group. VEGF and growth factor were measured by means
of immunohistochemiscal method and the density of the vessel was measured according to the
degree of factor expression. Results The expression of VEGF (80%) in bone marrow tissue from
HAPC patients was obviously higher than the control group (20%) (P<0.05). The density of
vessel in HAPC(10.02±6.18/HPF) was also higher than that of in control group 7.07±1.92/HPF
(P<0.05). Conclusion The density of vessel in HAPC patients was obviously higher than the
control group and the expression of VEGF increase significantly as well.
266.
MICROCIRCULATION IN BULBAR CONJUNCTIVA AND BLOOD PRESSURE OF
FIGHTER PILOTS AT AN IMITATE ALTITUDE OF FIVE THOUSAND METERS. Luo
Xinmin
1
, Lui Yin
1
, Xu Wenchao
2
, Li Gang.
1
. East-Lake Sanatorium of Chinese Airforce,
Wuhan
43
007
2
, China
1
, Gui Lin Sanatorium of Air Force, China
2
.
Objective The overall objective of this study is to assess the acute effect of hypobaric
pressure and hypoxia on microcirculation in bulbar conjunctival and arterial blood pressure
(ABP). Methods: Microcirculation in bulbar conjunctival and arterial blood pressure of fourteen
healthy fighter pilots were studied dynamically in a hypobaric chamber at a pressure of equivalent
to 5000 meters at different times: before and right after, ten-minute, twenty-minute, thirty-minute
after the beginning of the test. Results: All subjects tolerated acute hypoxia in the hypobaric
chamber reasonably well during the 30 min test. The significant increase of systolic arterial
pressure, pulse pressure and heart rate was observed with extended hypoxia (F test). With the
prolongation of the experiment, changes of microcirculation pattern, blood flow phenomenon and
total integral value of microcirculation in conjunctiva increased significantly (F test_P<0.01).
The integral value of blood vessels did not change remarkably (P<0.05). The dilation of venules
and markedly decreased number of blood vessels were also observed (P<0.01). There was no
significant difference in the number of arterioles (P0.05) before and after the test. By X2 test, the
instant clearance was indistinct (P<0.01). The velocity of bloodflow decreased during the tests of
ten to thirty-minute (P<0.01) and erythrocytes aggregation increased moderately (P<0.01). All
parameters return to normal after the test. Conclusions: The change of ABP is closely related to
the changes of diameter of venules and arteriole as well as to the aggregation of erythrocytes.
These changes improve the blood vessel conformity and heart function as a physiological
adaptation to the circumstances. It also showed that staying in hypobaric chamber at an imitate
altitude of five thousand meters is beneficial to cardiovascular function. This method will also
provide a theoretical basis for the treatment to coronary heart disease and hypertension at high
altitude.
267.
FIGHTER PILOTS BULBAR CONJUNCTIVA MICROCIRCULATION AND BLOOD
PRESSURE AT AN IMITATE ALTITUDE OF FIVE THOUSAND METERS. Lou Xinmin
1
,
Liu Ying
1
, Xu Wenchao
2
, Li Gang
1
. East-Lake Sanatorium of Chinese Airforce, Wuhan
43
007
2
,
China
1
, Gui Lin Sanatorium of Air Force, China
2
.
Objective Methods The bulbar cionjunctive microcirculation and biood pressure of fourteen
healthy fighter pilots were observed dynamically at different times: instant, ten-minute, twenty-
minute, thirty-minute before and after the test. The pilots stayed in the low pressure cabin at an
imitate alititude of five thousand meters. Results The pilots bore thirty-minute oxygen-shortage
and did not feel obviously unwell. The systolic arterial pressure pulse pressure and heart beat rate
increased significantly with extended oxygen-shortage (F test). With the prolongation of the
experiment all patterns flow-pattern and the total integral value of the microcirculation increased
significantly (F test_P<0.01). The integral value of blood-vessels did not change clearly
(P<0.05). The venules expanded and the numer of blood vessels decrease obviously (P<0.01).
Arterioles were not varied significantly (P0.05). By X2 test the instant clearance was indistinct
(P<0.01). The velocity of bloodflow slowed down druing ten to thirty-minute test (P<0.01). The
