score of 2.0 or higher on the SCL-90, 14.64% with depression and 11.72% with anxiety. There
were 194 males and 45 females in the group. Total mean score among males was 1.26±0.52 and
of females was 1.53±0.59.The gender difference reached statistical significance (p<0.01). A high
degree of obsessional symptoms in the PHI and positive scores on the SCL-90 correlate with the
duration of time working at high altitude (Pearson correlation=0.133, p<0.05 and Pearson
correlation=0.127, p<0.05). Conclusion: There is a high incidence of mental health problems
among workers building the Qinghai-Tibet Railway. Females demonstrated more severe
symptoms than males. Depression and anxiety were the most common mental health disorders
detected.
264.
OBSERVATION ON ULTRA-MICROSTRUCTURE OF CHORIONIC VILLI OF THE
PLACENTA AT HIGH-ALTITUDE. Bai Xin-Hua
1
, Ma Sheng-Xiu
1
, Huang Zhan-Hua
2
. Qinghai
Medical College Hospital, Xining, Qinghai, P.R. China
1
, Qinghai Medical College Hospital,
Xining, Qinghai, P.R. China
2
.
The objective of this study is to understand the development of the fetus in the mother's
body, and its relation to the structure of the chorionic villi of the placenta. Methods: To select 50
Han women at 38--42 weeks gestation in the Xining area (2260m), 37 Tibetan women in the
Guoluo area (3800m), and 50 Han women immigrated to a Tibetan area. We observe the ultra-
microstructure of chorionic villi of placenta of each group and compare them the chorionic
structure at low altitude (Shanghai). Result: The weight of new infants of native Tibetan group
was heavier than that of Han immigrants group, but showed no obvious differences compared
with Xining group. The weight of native Tibetan infants was lower than that of infants at low
altitude (p<0.05). The weight and volume of the placenta of the native Tibetan group was lower
than that of immigrated Han group but showed no clear differences with Xining and low altitude
areas(p0.05). Four variables were examined by light microscope: 1. syncytial node increases; 2.
blood syncytial membrane; 3. capillary increases; 4. fibrinoid necrosis. Each variable in the
Tibetan group was significantly different than that variable in the immigrated Han (p<0.01) but
was not significantly different with the Xining group (p0.05) and showed obvious differences
compared with the low altitude area. As analyzed by electron microscope, 1. The changes of
syntiotrophoblast cell: Tibetan group: the microvilli on the surface larger on average in the 39
Week's gestation group. As for 40-week gestation group, no obvious enlarging of the microvilli.
For 42-week group, it was short and rare and the rough surface endoplasmic reticulum became as
a vacuole. Immigrated group: the syntiotrophoblast cell started to change at the time of 39th
week, similar to Tibetan group of 40 weeks group, but 40-41 weeks, corresponded to the 42-week
Tibetan group. 2. The change of villi's quality: Tibetan group: The basement membrane showed
equal thickness and the syncytial membrane of vessel was in the shape of a rhombus in 39-week
group; at 42 weeks of each membrane had a different thickness; 42-week group showed
narrowing and fiber increasing. For the immigrated Han group, the 39-weeks group is similar to
the 40-week group of Tibetans, and the 40-week group is similar to the 41-42 week Tibetan
group. The Xining group was the same as the Tibetan group. Conclusion: Microvilli structure can
by affected by altitude hypoxia and become more serious with an increase in altitude. It can lead
to the lowered placenta function and lower weight of new infant.
265.
CHANGES IN BONE MARROW TISSUE MICRO VESSELS IN PATIENTS WITH HIGH
ALTITUDE POLYCYTHEMIA. Guo Xin-Jian
1
, Gou Xiao-Dan
1
, Ling Xiao-Qian
1
, Han Jing-Qi
1
,
Zhang Yi-Qing
1
, Yang Faman
2
, Li Zhanquan
2
. Dept. of Pathology, Qinghai Medical College
Hospital, Xining, Qinghai, P.R. China
1
, Dept. of hematology Qinghai Medical College Hospital,
Xining, Qinghai, P.R. China
2
.
High altitude polycythemia (HAPC) is a chronic disease relating to high altitude, low
atmospheric pressure and hypoxia. The pathogenesis of HAPC is still unclear. The purpose of this
study is to investigate the formation of micro vessels and Vascular Enthelium Growth Factor
(VEGF) expression in bone marrow tissue in patients with high altitude polycythemia. Methods
