To investigate the pathogenic character, morbidity and outcome between the delayed
resuscitation and the immediate resuscitation in burn patients with multiple organ dysfunction
syndrome (MODS) in the high altitude area. Methods: Referring to the two diagnostic standards
in domestic and abroad,65 (aged over 9) severely burned patients with MODS had been divided
into two groups,the delayed resuscitation group (group AN=30) and the immediate resuscitation
group (group B_N=35) in our hospital since 1991.We summed up and compared the morbidity
of SIRS, MODS and MOF of two groups. Results: Of 4 items to diagnose SIRS, all patients
accorded with over 2 items. The patients according with 3 items were 11 cases in group A and 18
cases in group B, and according with 4 items were one case in group A and 12 cases in group
B(P<0.005). The Morbidity of MODS, MOF and the mortality was 33.33%, 13.3%, 14.29%
respectively in the group A and 78.06%, 34.28%, 36.77% in group B. Conclusion: The higher
sensitivity and lower specialization of SIRS in severely burned patients appear in the high altitude
area. 2 Outcome of severely burned patients with MODS in the high altitude area is worse than
that in the plain area. 3 The disease incidences of SIRS, MODS and MOF in group A are
significant higher than those in group B in the high altitude area .
257.
EFFECT OF TRADITIONAL MEDICINES ON HEMORRHEOLOGY IN ACUTE
MOUNTAIN SICKNESS. Song Xiao-Hong
1
, Zhang Xin-Sheng
1
, Chu Yi-De
1
, Chu Xiao-Lin
2
.
Qinghai Provincial People's Hospital, Xining, Qinghai., P.R.China
1
, No.
4
Project Hospital of
Qinghai-Tibetan Railway, Germu City, Qinghai, China.
2
.
The purpose of the article is to discuss the effect of the YiXinKangTai on the hemorrheology
of acute mountain sickness and the possible pharmacological effects of Chinese and Tibetan
herbal medicines (FuFangDanSheng). Methods: 50 construction workers from the Qinghai-
Tibetan railway who developed acute mountain sickness after ascending to 4750m from low
altitude were randomly divided into 2 groups. 30 of them were given the YiXinKangTai, while
the other 20 were given FuFangDanSheng. Before and after taking the medicines, RBC, HGB,
HCT, _b, _p were determined for both groups. Results: There were no differences between the
groups in RBC, HGB, HCT, _b, _p before taking the medicine (p0.05). After taking the medicine
for one month, HCT, _b, _p of both groups decreased (p<0.05 - 0.01), while RBC, HGB
gradually decreased but without statistical significance (p0.05). The clinical effect of the
YiXinKangTai group was better than the FuFangDanSheng group. Conclusion: TCM cure
method of YiXinKangTai can improve hemorrheology function and reduce blood viscosity and
enhance the microcirculation tissues. It is an effective way to prevent acute mountain sickness.
Further research is needed to development treatments for acute mountain sickness using a
combination of Chinese and Western medicine and to modernize mountain sickness prevention
by using Chinese herbal medicine and Tibetan herbal medicine.
258.
EFFECTS OF HYPOXIA ON LEVELS OF NITRIC OXIDE, ENDOTHELIN-1 AND
INDUCIBLE NITRIC OXIDE SYNTHASE MRNA EXPRESSION IN CULTURED HUMAN
UMBILICAL VEIN ENDOTHELIAL CELLS. Hu Xiaolan
1
, Lin Shuxin
1
, Yu Daihua
1
, Zhang
Shifan
2
. Department of Pathophysiology, Fourth Military Medical University
1
, Department of
Thoracic Cardiovas Surgery, Lanzhou General Hospital of PLA
2
.
To observe the effects of hypoxia on the levels of NO ET-1 and the expression of iNOS
mRNA in human umbilical vein endothelial cells(HUVECs), and further investigate the
mechanism of hypoxic pulmonary hypertension. METHODS: On the basis of the HUVECs
culture model, the methods of nitrate reductase and radioimmunoassay were used to determine
the changes of NO and ET-1 in the medium secreted by HUVECs, and the expression of
iNOSmRNA was analyzed by semi quantitative RT-PCR after exposure to hypoxia(3%O2) for 6,
12 or 24 hours. RESULTS: The contents of NO2-/ NO3-and ET-1 of hypoxia group in the
medium was significantly higher than that of control group at different time points (P<0.01).
Also, iNOSmRNA expression increased significantly (P<0.01). CONCLUSION: hypoxia could
