attention should be given to these factors during the treatment at high altitude, especially during
the emergency treatment of serious ill patients.
245.
CHANGES AND CLINICAL SIGNIFICANCE OF MULTIPLE ORGAN FUNCTION
INDEXES AFTER THORACIC OPERATION AT MODERATE HIGH ALTITUDE. Lu
Wensheng
1
, Zhang Shifan
2
, Cao Xuewen
1
, Jiang Junwei
1
, Yang Yongzhu
1
, Zhang Dehai
2
, Gao
Wei
2
. Department of Thoracic Cardiovas Surgery, the Second Affiliated Hospital of Lanzhou
Medical College
1
, Department of Thoracic Cardiovas Surgery, Lanzhou General Hospital of
PLA
2
.
Objective: To study the dynamic changes of multiple organ function indexes around thoracic
surgery performed on the moderate high-altitude(1517m). Methods: 20 cases of patients with
esophageal cancer were chosen and thirty three organ indexes were recorded before and after
operation. The changes of organ indexes were analyzed with the system of APACHE and the
criteria of MODS and SIRS. Results: The change range of arterial blood gases were great and
PaO2/FiO2, AaDO2 changed significantly (P<0.01). The indexes accorded with the criteria of
item SIRS 2-4 on the 1, 3 and 5th day after operation were 100%, 90%, and 60% respectively,
and on the 1 and 2nd day all of them reached ALI criteria; platelet count, glutamic-oxalacetic
transaminase, Na+ and blood sugar changed significantly around the operation (P<0.05, P<0.01).
Conclusion: Thoracic surgery influenced multiple organ function indexes greatly on the moderate
high-altitude. It show the criteria of ARDS/MODS at moderate high-altitude were different from
that of the plain and so a more practicable diagnostic criteria for the patients of moderate high-
altitude is in urgent need.
246.
PROSPECTIVE STUDY OF PREVENTING ACUTE LUNG INJURY IN USING CHINESE
DRUG RHODIOLA COMPOUND BEFORE THORACIC OPERATION AT MODERATE
HIGH ALTITUDE. Lu Wensheng
1
, Zhang Shifan
2
, Cao Xuewen
1
, Jiang Junwei
1
, Yang
Yongzhu
1
, Zhang Dehai
2
, Gao Wei
2
. Department of Thoracic Cardiovas Surgery, the Second
Affiliated Hospital of Lanzhou Medical College
1
, Department of Thoracic Cardiovas Surgery,
Lanzhou General Hospital of PLA
2
.
Objective: To study the pathogenesis and the preventive treatment of acute lung injury (ALI)
caused by thoracic operation at moderate high altitude. Methods: 36 patients with esophageal
cancer, cardiac cancer were chosen and divided into contrasting group (CG n=20) and treating
group (TG n=16). The treatment of routine both in CG and TG was similar, but in TG 3.2 grams
of rhadiola compound (RCO) were used every day for a period of 7_10 days preoperatively.
Thirty three organ indexes were examined and recorded and compared in each groups. Results:
Before operation PaO2/FiO2 of the two groups was 280_370mmHg, and there were 5 cases
PaO2/FiO2300mmHg in CG and 3 cases in TG, AaDO2 was between 18-37mmHg and there
were not significant differences between them (P0.05). The changing ranges of arterial blood gase
were great and there were significant differences and it showed that injury degrees of TG were
lower than those of CG. All the two groups reached ALI criteria and most of them reached the
criteria of ARDS. There were 18 cases (90%) and 12 cases (60%) in CG and 14 cases (87.5%)
and 9 cases (56.25%) in TG reached the criteria of item SIRS 2, 4 on 2 and 3rd day after
operation. The mortality rate were 5.0% in CG. Conclusion: SIRS, ALI could be induced easily
by thoracic operation on the moderate high altitude and it showed that the present common
diagnostic criteria of ARDS didn't apply to moderate high altitude. Early use of RCO may protect
against major risk factors of ALI/ARDS caused by thoracic operations.
247.
ROOM OXYGEN ENRICHMENT. John West
1
. University of California, San Diego
1
.
Oxygen enrichment of room air is proving to be an important advance in improving the
productivity and quality of life of lowlanders who are required to work at high altitude. The
principle is simple. Oxygen is produced from air using zeolite concentrators that preferentially
