243.
EVALUATION OF SOME COMPOUND ZANG DRUGS TO IMPROVE
ACCLIMATIZATION OF YOUNG MEN AT HIGH ALTITUDE. Niu Wen
1
, Wang Yi
1
, Zhang
Jin-Jun
2
, Wang Hong-Jun
1
, Chen Ning-Rong
1
. Center of disease prevention and control, Chengdu
military command, Chengdu, China
1
, Clinic of Xinhua east road cadre sanatorium of Chengdu
military command, Chengdu, China
2
.
In order to probe into a new method to improve the acclimatization of human body at high
altitude and the application of traditional Zang and Chinese drugs to prevention from acute
mountain sickness, some compound Zang and Chinese drugs were studied. 170 subjects who
would be sent to high altitude (HA) by airplane were divided randomly into six groups, and they
were given Luobusang, Nuodikang, Zangwangbao, Hongjingtian, Di'ao Xinxuekang and placebo,
respectively. A single blind procedure of administration was used. Before they entered HA
(above sea level 3900 m) three days, they took different drug according to their group, 2 capsules
each time, three times a day for 6 days. The incidences of hypoxic symptoms of these six groups
were investigated from the first day to the fifth day when they entered HA. Meanwhile, before
they took the drugs and after they entered HA 5 days, their heart functional index (HFI),
electrocardiogram (ECG), ventilation efficiency index (VEI), breath holding index (BHI) and HA
adaptation index (HAAI) were measured, respectively. The results showed that 1. The incidence
of hypoxic symptoms is highest in the first day at HA, and then went gradually down to the least
at the fifth day. There were significant differences of the incidence among these six groups at the
first day and the third day. 2. During the early stage after they were exposed to HA, all of their
HFI decreased, but the decreases of HFI of Luobusang group, Nuodikang group and Di'ao
Xinxuekang group were not significant (p0.05), compared with those in the lowland (above sea
level 500 m). Although the HFI of Luobusang group decreased, but its HFI evaluation rank at HA
was still the same as that in lowland, and the HFI evaluation ranks of other groups at HA were
lower than those in low land. 3. All of their VEI decreased remarkably at HA (p<0.01). Among
six groups, BHI of Luobusang and Nuodikang groups were higher at HA than those in the
lowland, but only Luobusang group's BHI was higher than the control's at HA (p<0.01).
Compared with those of other groups, the HAAI of Di'ao Xinxuekang was higher and there were
not any differences among other groups. 4. All of their ECG were not different significantly
before they entered HA(P0.05). But after they entered HA, the heart rate of the control group
beated faster, Q-T and QT/TQ ratio increased, and the amplitude of RS wave decreased. These
changes of the control group were different significantly from those of drug groups (P<0.05-
0.01). Based on our study, it is suggested that all of these drugs have some effects against hypoxia
and improving HA acclimatization, except of Zangwangbao. But compared with the other drugs,
it is considered that the effects of both Luobusang and Di'ao Xinxuekang perhaps are better.
244.
A STUDY OF COAGULATION-FIBRINOLYSIS IN NORMAL SUBJECTS AT DIFFERENT
ALTITUDE. Li Wen-Qian
1
, Feng Jian-Ming
1
, Shen Kuo
1
, Han Guo-Xiong
1
, Wang Li
1
, Sun Zhi-
Xin
2
. Qinghai Provincial People's Hospital, Xining,, Qinghai, P.R. China
1
, Qinghai Provincial
People's Hospital, Xining,, Qinghai, P.R. China
2
.
To study the changes in coagulation and fibrinolysis in normal subjects at different altitudes.
Method The subjects were divided into a lowland group (50m, n=34), a Germu group (2800m,
n=23) and a Tuotuo River group (4700m, n=34). Their blood samples were tested by an auto-
analyzing coagulation instrument. We measured prothrombin time (PT), thrombin time (bleeding
time) (tt), activated partial thromboplastin time (APTT), fibrinogen (FBG), plasminogen (PLG),
plasmin inhibitor (PL-IN) and D-dimer (DD). Results: PL-IN in the Germu group was lower than
that of the lowland group but PD and DD were higher (p<0.05). PT, TT, APTT and DD in the
Tuotuo River group were higher than those of the lowland group but FBG, PLG and PL-IN were
lower (p<005). These results showed high coagulation of blood and strengthening of fibrinolysis.
Conclusion: The coagulation-fibrinolysis system of normal subjects who come into altitude
changed. This may be due to altitude hypoxia, endothelial damage and polycythemia. More
