disease in C group was 1.8±0.7d, all of which were significantly different from those of the B
group (2.4±1.4d, 4.1±1.7d, 6.8±1.8d, respectively) and the A group (3.7±1.2d, 5.5±1.8d,
9.6±3.1d, respectively). Inhaling NO can quickly retro convert pulmonary hypertension related to
hypoxia (3~5min). We found in our study that inhaling low concentration NO on the basis of
regular and nifedipine therapies is a new and very effective method in treating HAPE. This new
combined therapy shortens the course of HAPE significantly in contrast to regular therapy, is
more safe and reliable, and deserves generalization.
239.
THE EFFECT OF GINGKGO BILOBA ON THE SUBMAXIMAL EXERCISE HEART RATE
OF IMMIGRATED YOUTH AT HIGHLANDS. Wang Wei
1
. The
1
8th Hospital PLA, Yecheng
Xinjiang, China
1
.
The goals of this study were to investigate the effect of gingkgo biloba on the sub maximal
exercise heart rate of immigrated youth at high altitude. We randomly divided 20 youths who had
lived at 3700m for 6 months into 2 groups (each group having 10 men). The control group (CG)
took 2 placebo capsules, bid; the experimental group (EG) took 2 gingkgo bilobas tablets, bid. All
subjects underwent bicycle ergo meter (EGM style) exercise at 60rpm until exhausted before
taking the medicine and for 15 days after. The initial load was set to 25W and increased by 25W
every 3 min. Each subject's exercise heart rate was analyzed at 90W by linear regression
(HR90W). The results show that HR90W of the EG before and after taking ginko biloba is
123.89±7.69 and 112.81±6.54. HR is much lower after taking ginko biloba and has a significant
difference (P<0.01); HR90W of CG before and after taking medicine is 124.78±6.39,
125.67±7.65, and, therefore, is not a significant difference. Taking gingkgo biloba can
significantly improve the work efficiency of immigrated youth on the plateau.
240.
THE EXPRESSION OF PLASMA PROTEIN C AND PROTEIN S IN HEALTHY
POPULATION AND PATIENTS OF HIGH ALTITUDE POLYCYTHEMIA. Luo Wei
1
, Jia Nai-
Yong
1
, Li Zhan-Quan
1
, Yang Fa-Man
1
, Cui Sen
1
, Chai Ke-Xia
2
, Ji Lin-Hua
1
, Li Yu-Li
1
.
Affiliated hospital of Qinghai Medical College, Xining, Qinghai, P. R. China
1
, Affiliated hospital
of Qinghai Medical College, Xining, Qinghai, P. R. China
2
.
At high altitude epistaxis and gingival bleeding occur in the healthy population and in
patients with high altitude polycythemia. A great number of research indicates that the coagulant
activity is elevated in healthy subjects at high altitude; however, anticoagulant activity at high
altitude is unknown. The aim of this study is to explore the expression of protein C PC and
protein S_PS_in a population at high altitude and investigate the relationship between the
changes in the anticoagulant system and hypoxia. Methods: The plasma concentrations of PC
total PS TPS and free PS FPS in 17 patients with high altitude polycythemia HAPC were
measured by solid phase sandwich enzyme linked-immuno-sorbent assay ELISA . The patients
were composed of 15 healthy Tibetan natives and 40 immigrants living at altitude of 4300m for
different lengths of time In addition the PC TPS and FPS were measured in 15 healthy natives
who were living at an altitude of 2260m Xining as a control group Results: The levels of PC and
PS in Tibetan natives and acclimatized immigrants were significantly higher than that of control
group p<0.001 and the plasma levels of PCTPSFPS were highly positive correlation with the
residential time at high altitude r=0.836-0.874-0.853p<0.001 2 The plasma levels of PC TPS and
FPS in patients with HAPC were significantly lower compared to the other groups and the plasma
levels of PC TPS and FPS were negatively correlated with Hgb r=-0.887 -0.870 -0.879 p<0.001
Conclusion These results indicate that 1 the anticoagulant activity is elevated in healthy subjects
at high altitude which is at least in part it is believed, to be one of the compensatory responses for
acclimatizing to high altitude. 2 the decreasing activity of anticoagulation in patients with HAPC
may be one of the pathological basis in development of HAPC.
