Find Docs

Pepscan Systems - Transport Peptide (Page 1)

Wodocs >> Business : Biotechnology and Pharmaceuticals >> Pepscan Systems Transport Peptide Page 1
Pepscan Systems - Transport Peptide
Property of Pepscan Systems BV
1of 1
Confidential
A Novel Class of Transport Peptides for Enhanced Drug Delivery
Pepscan Systems' XMTM
A major challenge in today's biotechnological drug development is the fact that, on one
hand, many recombinant products such as bioactive proteins, enzymes, and antibodies,
and on the other hand, antisense oligonucleotides and gene constructs, have inherent
unfavorable pharmacokinetic properties due to their physicochemical nature. None of
these molecules have the ability to readily penetrate cell membranes and the body's
physiological barriers to reach their pharmacological targets in the body. This problem
also applies to many conventional "small molecule" drug candidates. The phenomenon
usually leads to low in vivo "effective availability", that is the amount of drug that
eventually reaches its site of action, a problem that either makes otherwise promising
molecules unsuitable for drug therapy or, alternatively, leads to approaches that try to
circumvent the problem by using uneconomically high dose levels (with an inherent
safety and tolerability risk) often combined with patient unfriendly routes of
administration and complicated therapeutic regimens.
Pepscan's novel delivery system XMTM consists of a modified and optimized peptide,
that originates from the E
rns
viral surface protein to which Pepscan's proprietary peptide
optimization technology was applied. We have demonstrated in several experimental
models that the XMTM molecule is able to translocate a conjugate consisting of XMTM
peptide and molecular cargo such as a large protein or oligomer across cell membranes.
Figure 1 depicts the in vitro uptake of functional
-Galactosidase tetramer, a protein
complex with a total molecular weight of 550 kDa, which is otherwise unable to
penetrate cell membranes due to its size and hydrophilic nature.

<< Previous      1 2 3 4       Next >>



Other Documents:
Pep Scanentersresearchcoll, Pepscan Systems Launches Pepchip, Pepscanreports 2003, Saint Pepscan, SC Order Form, Heating, city sj motion, application, specs, Holiday Shopping, specs, CL. Fact Sheet, CL. PR.neworg.2002, CLCS.brochure.2002, Mass. General Hospital, limncontract, 158, August 152005, May 062005, September 062005, networkingtips, MTG Bilaga 6 CHP, traineeannons 020315, 2006 Incentive Program, MTG note 28 en, signartwork, barpg 46, barstoolpgs 32 33, basepg 5, bedpg 53, bedpg 55, bwpages 31 35, bwpages 36 40, spw application, opinions guidelines, poetry guidelines, Entry Form, teacher guide, membership agreement, EF 2003 Pricelist, Branch Pages from EF 2003 Pricelist, Flowering Pages from EF 2003 Pricelist 1, Fruits Veg Pages from EF 2003 Pricelist 1, Grasses Pages from EF 2003 Pricelist 1, holiday pricelist, index 2, index 2, index 2i, index 2, Constitution Revise S 04,

Wodocs share you 300000 free online manuals, brashures and other documents, some pages can be downloaded.

if you have any questions about Transport Peptide online manual, please feel free to contact us
if you can't find Pepscan Systems user, owners manual, operating instructions, service manual, quick start guide, mounting,
and installation instructions, RTFM, schematics and user guide, please use search box or contact us.

All copyrights, pictures, pdfs, trademarks and brands are the property of their owners.


WODocs | |
All rights reserved. wodocs.comę 2009
WODocs


New Docs

Documents Category:
Arts (Design, Movies, Music, Radio, Television)
Automotive (Cars, Marine, Motorcycle, ATV, Snowmobiles)
Business (Biotechnology and Pharmaceuticals, Chemicals, Construction and Maintenance, Materials, Real Estate, Services)
Electronics (Computers, Motion Control, Power Supply)
Games (Board, Family, Party, Card, Construction, RC Toys)
Health (Animalm, Beauty, Healthcare, Medicine, Pharmacy, Surgery, Weight Loss)
Home (Accessories, Cooking, Decor and Design, Electrical, Family, Pets)
News (Newspapers, Sports, Television)
Recreation (Collecting, Hiking, Scouting, Survival, Travel)
Reference (Education, Libraries and Archives, Museums)
Science (Agriculture, Astronomy, Biology, Chemistry)
Shopping (Antiques and Collectibles, Clothing, Flowers, Food, Home and Garden)
Sports (Bicycle, Snowboard, Skiing, Other)