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Mimura T, Relationship between HLA and retinopathy in patients with type 1 diabetes
Blood samples were collected after informed consent was obtained from each subjects
following an explanation of the purpose. This study was performed in accordance with
the 1975 Declaration of Helsinki, as revised in 1983. The patients who had been
diagnosed under 30 yr of age (range; 13-28 years old) and have Type 1 diabetes
duration for more than 10 years, who receive treatment at Tokyo Women's Medical
University Diabetes Center were enrolled into the study. The younger-onset individuals
are the focus of this report. We excluded patients with the slowly progressive Type 1
diabetes from these.
The PDR group was consisted of 30 patients, who had undergone vitreous surgery
under 40 years old (28.4 ± 6.5, mean
± standard deviation) at the outpatient clinic of
the Department of Ophthalmology, Diabetes Center Tokyo Women's Medical
University (Tokyo, Japan) during the period of 1993 to 1999. The gender-matched
non-DR group consisted of 50 patients who had no signs of retinopathy despite
diabetes duration for more than 10 years. We have matched the gender, the diabetes
duration and the blood glucose control between the two groups. The control group
selected for comparison, consisted of 50 healthy patients (Table 1). HbA1c level was
determined with resin microcolumn technique (HPLC, Kyoto Chemical) (normal
range: 4.3-5.8%).
