Mimura T, Relationship between HLA and retinopathy in patients with type 1 diabetes
PURPOSE: To investigate the relationship between human leukocyte antigen (HLA)
status and proliferative diabetic retinopathy (PDR) to assess the genetic basis of PDR
in younger Type 1 diabetic patients.
DESIGN: Retrospective, nonrandomized, comparative traial.
METHOD: Patients who were diagnosed with Type 1 diabetes under 30 years of age
(13-28 years) and had a disease duration of more than 10 years were studied. The
patients were divided into two groups: 30 patients who had undergone vitreous surgery
under 40 years old (the PDR group) and 50 patients without retinopathy (the non-DR
group). The duration of diabetes and the level of glycemic control were matched
between the two groups. The control group consisted of 50 healthy patients. HLA-A,
-B, -C, -DR, and -DQ typing of blood samples was done using the standard
RESULTS: The frequency of HLA-B62, Cw4, and DQ4 was significantly higher in
the PDR group than in the non-DR group (P = .0020, P = .048, and P = .0026,
respectively). The Cw4-DR4-DQ4 haplotype frequency was significantly higher in the
PDR group than in the control group and the non-DR group (P = .0059, respectively).
CONCLUSION: Our results suggests that HLA-B62, Cw4 and DQ4 may be useful