American Journal of Ophthalmology AJO 2892 Page 15
Page 15
Mimura T, Relationship between HLA and retinopathy in patients with type 1 diabetes
Table 3. HLA-DQ and -DR Antigen Frequencies (%) in Each Group
Control
group
non-DR
group
PDR
group
2
P value
Relative
Risk
DR1 4
(8.0)
5
(10.0)
4 (13.3)
0.209
NS
1.385
DR2 17
(34.0)
3
(6.0)
5 (16.7)
2.370
NS
3.133
DR3 0
(0.0)
5
(10.0)
0 (0.0)
3.200
NS
0.000
DR4 19
(38.0)
32
(64.0)
16 (53.3)
0.889
NS
0.643
DR6 15
(30.0)
13
(26.0)
7 (23.3)
0.071
NS
0.866
DR7 1
(2.0)
0
(0.0)
2 (6.7)
1.131
NS
3.500
DR8 12
(24.0)
13
(26.0)
8 (26.7)
0.004
NS
1.035
DR9 12
(24.0)
21
(42.0)
13 (43.3)
0.014
NS
1.056
DR10 1
(2.0)
0
(0.0)
0 (0.0)
0.000
NS
1.000
DR11 1
(2.0)
1
(2.0)
0 (0.0)
0.608
NS
0.000
DR12 2
(4.0)
1
(2.0)
1 (3.3)
0.137
NS
1.690
DR13 9
(18.0)
0
(0.0)
0 (0.0)
0.000
NS
1.000
DR14 7
(14.0)
1
(2.0)
1 (3.3)
0.137
NS
1.690
DRHR5 1
(2.0)
0
(0.0)
0 (0.0)
0.000 NS 1.000
DRHR6 2
(4.0)
0
(0.0)
0 (0.0)
0.000 NS 1.000
DR52 18
(36.0)
17
(34.0)
7 (23.3)
1.016 NS 0.591
DR53 34
(68.0)
34
(68.0)
23 (76.7)
0.688 NS 1.546
DQ1 36
(72.0)
17
(34.0)
10 (33.3)
0.004
NS
0.971
DQ2 0
(0.0)
3
(6.0)
1 (3.3)
0.281
NS
0.540
DQ3 28
(56.0)
31
(62.0)
20 (66.7)
0.177
NS
1.226
DQ4 15
(30.0)
21
(42.0)
23 (76.7)
9.104
.0026
4.537
DQ6 (1)
6 (12.0)
7 (14.0)
2 (6.7)
1.010
NS
0.439
DQ7 5
(10.0)
2
(4.0)
0 (0.0)
1.231
NS
0.000
Comparisons between the PDR group and the non-DR group are shown. Numbers in parentheses
are percentages. NS = not significant.
Table 4. Haplotype Frequencies (%) in Each Group
Control
group
non-DR
group
PDR
group
2
P value
Relative
Risk
B62-Cw4 1 (2.0)
1 (2.0)
2 (6.6)
1.131
NS
3.5
B62-DR4 1 (2.0)
0 (0.0)
2 (6.6)
3.419
NS
-
B62-DQ4 0 (0.0)
0 (0.0)
8 (26.7)
14.815
.0020
-
Cw4-DR4 0 (0.0)
0 (0.0)
5 (16.7)
8.889
.0059
-
Cw4-DQ4 0 (0.0)
0 (0.0)
5 (16.7)
8.889
.0059
-
DR4-DQ4 5 (10.0)
16 (32.0)
14 (46.6)
1.721
NS
1.86
B62-Cw4-DR4 0 (0.0)
0 (0.0)
2 (6.6)
3.419
NS -
B62-Cw4-DQ4 0 (0.0)
0 (0.0)
2 (6.6)
3.419
NS -
B62-DR4-DQ4 0 (0.0)
0 (0.0)
2 (6.6)
3.419
NS -
Cw4-DR4-DQ4 0 (0.0)
0 (0.0)
5 (16.7)
8.889
.0059
-
B62-Cw4-DR4-DQ4 0 (0.0) 0 (0.0) 2 (6.6) 3.419
NS
-
Comparisons between the PDR group and the non-DR group are shown. Numbers in parentheses
